Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function

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dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridKARAKAS, SERDAR/0000-0001-8314-7806
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidKARAKAS, SERDAR/AAB-3219-2021
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorKarakas, Serdar
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorInce, Volkan
dc.contributor.authorAkbulut, Sami
dc.contributor.authorDalda, Yasin
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorKahraman, Aysegul Sagir
dc.date.accessioned2024-08-04T20:10:21Z
dc.date.available2024-08-04T20:10:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aim: Liver resection (LR) and liver transplantation (LT) are curative treatments for hepatocellular carcinoma (HCC). The main pur-pose of this study was to compare the survival of LR and LDLT in patients with HCC within the Milan criteria. Materials and Methods: The results of the LR (n=67) and LDLT (n=391) groups were compared for overall survival (OS) and disease-free survival (DFS). Twenty-six of the HCCs in the LRs met the Milan and Child A cri-teria. Also, 200 of the HCC patients in the LDLTs met the Milan criteria, of which 70 also met the Child A criteria. Results: Early mortality was higher in the LDLT group (13.9% vs 1.47%; p=0.003). The 5-year OS was higher in the LDLTs than the LRs, but not statistically significant (84.6% vs 74.2%; p=0.287). However, 5-year DFS was better in the LDLT group (96.8% vs 64.3%; p<0.001). When the LRs (n=26) and the LDLTs (n=70) that met both Milan and Child A criteria were compared, 5-year OS was similar (81.4% vs 74.2%; p=0.512), but DFS was better in the LDLTs (98.6% vs 64.3%; p<0.001). Conclusion: LR can be justified as the first-line treatment for HCC patients who meet Milan and Child A criteria in terms of and OS.en_US
dc.identifier.doi10.14744/hf.2023.2023.0005
dc.identifier.endpage52en_US
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue2en_US
dc.identifier.pmid37250925en_US
dc.identifier.scopus2-s2.0-85164314245en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage47en_US
dc.identifier.trdizinid1178884en_US
dc.identifier.urihttps://doi.org/10.14744/hf.2023.2023.0005
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1178884
dc.identifier.urihttps://hdl.handle.net/11616/92730
dc.identifier.volume4en_US
dc.identifier.wosWOS:001000795000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectliver resectionen_US
dc.subjectliver transplantationen_US
dc.titleComparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver functionen_US
dc.typeArticleen_US

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