Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)

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dc.authoridSahin Ozdemirel, Tugce/0000-0003-1596-0082
dc.authoridAYDIN, Derya/0000-0002-1511-4663
dc.authoridŞentürk, Ayşegül/0000-0002-1072-0592
dc.authoridBayram, Mustafa/0000-0002-2994-7201
dc.authoridBülbül, Yilmaz/0000-0002-8488-3650
dc.authoridNiksarlıoğlu, Elif Yelda/0000-0002-6119-6540
dc.authoridCelik, Gökhan/0000-0003-0869-8979
dc.authorwosidComert, Sevda Sener/HJH-4482-2023
dc.authorwosidOZCELIK, Ali Erdem/GPF-5162-2022
dc.authorwosidIliaz, Sinem/GZG-7543-2022
dc.authorwosidSahin Ozdemirel, Tugce/HLH-3244-2023
dc.authorwosidAYDIN, Derya/GQB-1218-2022
dc.authorwosidŞentürk, Ayşegül/CAF-0331-2022
dc.authorwosidBayram, Mustafa/AAA-4023-2020
dc.contributor.authorOzcelik, Neslihan
dc.contributor.authorAksel, Nimet
dc.contributor.authorBulbul, Yilmaz
dc.contributor.authorErdogan, Yurdanur
dc.contributor.authorGuldaval, Filiz
dc.contributor.authorGul, Sule Karabulut
dc.contributor.authorBircan, Ahmet
dc.date.accessioned2024-08-04T20:10:00Z
dc.date.available2024-08-04T20:10:00Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: The results of standard chemotherapy in lung cancer are not very satisfactory, so it is important to identify genetic mutations that provide targeted therapies. Recent reports have suggested influences of racial difference on the frequency of mutation in lung cancer. We aimed to determine the frequency and regional distribution of genetic mutations of non-small cell lung cancer (NSCLC) in Turkey. Materials and Methods: Regional distribution of genetic mutations in lung cancer in Turkey (REDIGMA) study was carried out as a prospective, cross-sectional, observational study in a large number of centers in which lung cancer patients were followed and could perform genetic mutation analysis on patients' biopsy materials. Results: The 703 patients (77.7% male, mean age 63.3 +/- 12.5 years) who were diagnosed as NSCLC from 25 different centers were included in the study. Tumor samples from patients were reported as 87.1% adenocarcinoma, 6.4% squamous cell carcinoma and 6.5% other. Mutation tests were found to be positive in 18.9% of these patients. The mutations were 69.9% EGFR, 26.3% ALK, 1.6% ROS and 2.2% PDL. Mutations were higher in women and non-smokers (p < 0.000, p < 0.001). Again, the frequency of mutations in adenocarcinoma was higher in metastatic disease. There was no difference between the patient's age, area of residence, comorbidity and clinical stage and mutation frequency. Conclusion: Our study revealed that the EGFR mutation rate in Turkey with NSCLC was similar to East European, African-American and Caucasian patients, and was lower than in East Asia.en_US
dc.identifier.doi10.5578/tt.68707
dc.identifier.endpage204en_US
dc.identifier.issn0494-1373
dc.identifier.issue3en_US
dc.identifier.pmid31709951en_US
dc.identifier.scopus2-s2.0-85074742012en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage197en_US
dc.identifier.trdizinid352866en_US
dc.identifier.urihttps://doi.org/10.5578/tt.68707
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/352866
dc.identifier.urihttps://hdl.handle.net/11616/92551
dc.identifier.volume67en_US
dc.identifier.wosWOS:000493372200006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.ispartofTuberkuloz Ve Torak-Tuberculosis and Thoraxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectALKen_US
dc.subjectEGFRen_US
dc.subjectcarsinomaen_US
dc.subjectnon-small cell lung canceren_US
dc.subjectTurkeyen_US
dc.subjectregional distributionen_US
dc.titleRegional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)en_US
dc.typeArticleen_US

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