EFFECT OF MINOCYCLINE AND MINOSCYCLINE+METFORMIN ON EXPERIMENTAL DIABETES-RELATED DEPRESSION

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dc.authorscopusid57908630200
dc.authorscopusid6604007154
dc.authorscopusid56868482500
dc.authorscopusid55217729300
dc.contributor.authorİNci? Çamçi M.
dc.contributor.authorErdi?Nç M.
dc.contributor.authorUyar E.
dc.contributor.authorKelle İ.
dc.date.accessioned2024-08-04T20:03:45Z
dc.date.available2024-08-04T20:03:45Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Minocycline is a second-generation tetracycline group antibiotic that acts on the central nervous system. Minocycline reduces microglial activation and has anti-inflammatory, anti-apoptotic, and antioxidant properties. Recently, it has been proposed that there is a bidirectional relationship between diabetes and depression and that inflammation is one of the common pathways in their pathophysiology. The effects of minocycline on depression were then investigated. This study aimed to reveal the effects of minocycline alone or in combination with metformin, which is used in the treatment of diabetes, on diabetes-related depression. Material and Method: For this purpose, to establish a human-like type 2 diabetes model in mice, streptozotocin (STZ) (50mg/kg) was administered once a day for five consecutive days after a 4-week high-fat diet. Animals with blood glucose levels ?200 mg/dl were considered diabetic and employed in this experiment. Minocycline (40 mg/kg), fluoxetine (20 mg/kg), and metformin (200 mg/kg) were given once a day for 7 days two weeks after STZ injection. After the drug injections were completed, an open field test was used to determine locomotor activity and a forced swimming test was used to determine depression level. Result and Discussion: It was concluded that diabetes and the drugs administered did not induce a significant change in locomotor activity, and that the minocycline and minocycline-metformin combination was at least as effective as fluoxetine in treating depression. It is recognized that the initiation of antidepressant effects in a short period is critical for patient adherence to therapy and diabetes prognosis. In conclusion, antidepressant-like effects of subchronic minocycline treatment appear to be potent as classical antidepressants. The mechanisms underlying minocycline's effects on mood should be broadly investigated to increase our understanding of depression and unveil potential novel therapies in depression management. © 2022 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.1098642
dc.identifier.endpage443en_US
dc.identifier.issn2564-6524
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85138971662en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage432en_US
dc.identifier.trdizinid1118909en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1098642
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1118909
dc.identifier.urihttps://hdl.handle.net/11616/92041
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDepressionen_US
dc.subjectdiabetesen_US
dc.subjectminocyclineen_US
dc.titleEFFECT OF MINOCYCLINE AND MINOSCYCLINE+METFORMIN ON EXPERIMENTAL DIABETES-RELATED DEPRESSIONen_US
dc.title.alternativeDENEYSEL DİYABETİN NEDEN OLDUĞU DEPRESYON TEDAVİSİNDE MİNOSİKLİN VE MİNOSİKLİN+METFORMİN KULLANIMIen_US
dc.typeArticleen_US

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