Evaluation of a collagen-bioaggregate composite scaffold in the repair of sheep pulp tissue

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dc.authoridDAYI, Burak/0000-0002-5289-438X
dc.authorwosidEröksüz, Hatice/W-4280-2018
dc.authorwosidDAYI, Burak/ABH-6633-2020
dc.contributor.authorDaya, Burak
dc.contributor.authorBilecen, Deniz Sezlev
dc.contributor.authorEroksuz, Hatice
dc.contributor.authorYalcin, Muhammet
dc.contributor.authorHasarca, Vasaf
dc.date.accessioned2024-08-04T20:10:14Z
dc.date.available2024-08-04T20:10:14Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description21st BaSS Congress on Effect of Collagen-Bioaggregate Scaffold on Perforated Dental Pulp -- MAY 12-15, 2016 -- Banja Luka, BOSNIA & HERCEGen_US
dc.description.abstractPurpose This study aimed to compare the effects of the collagen-BioAggregate mixture (CBA-M) and collagen-BioAggregate composite (CBA-C) sponge as a scaffolding material on the reparative dentin formation. Materials and Methods CBA-C sponge (10:1 w/w) was obtained and characterized by Scanning Electron Microscopy (SEM) and Mercury Porosimetry. Cytotoxicity of the CBA-C sponge was tested by using the L929 mouse fibroblast cell line. Dental pulp stem cells (DPSCs) were isolated from the pulp tissue of sheep teeth and characterized by flow cytometry for the presence of mesenchymal stem cell marker, CD44. The osteogenic differentiation capability of isolated DPSCs was studied by Alizarin Red staining. The cells were then used to study for the compatibility of CBA-C sponge with cell proliferation and calcium phosphate deposition. The effect of CBA-C sponge and CBA-M on the induction of dentin regeneration was studied in the perforated teeth of sheep for the eight-week period. All the analyses were performed with appropriate statistical hypothesis tests. Results CBA-C sponge was found to be biocompatible for DPSCs. The DPSCs seeded on the CBA-C sponge were able to differentiate into the osteoblastic lineage and deposit calcium phosphate crystals in vitro. Reparative dentin formation was observed after the second week in the CBA- C sponge applied group. At the end of eight weeks, a complete reparative dentin structure was formed in the CBA-C sponge applied group, whereas necrotic tissue residues were observed in groups treated with the CBA-M. Conclusion CBA-C sponge represents a better microenvironment for reparative dentin formation probably due to maintaining DPSCs and allowing their osteogenic differentiation and thus calcium phosphate deposition.en_US
dc.description.sponsorshipBaSSen_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112S584]; Research Fund of the Inonu University [2013/80]en_US
dc.description.sponsorshipThis work was funded by the Scientific and Technological Research Council of Turkey (TUBITAK), Grant No: 112S584 and by the Research Fund of the Inonu University, Project Number: 2013/80.en_US
dc.identifier.doi10.26650/eor.2021911441
dc.identifier.endpage161en_US
dc.identifier.issn2630-6158
dc.identifier.issn2651-2823
dc.identifier.issue3en_US
dc.identifier.pmid34746787en_US
dc.identifier.scopus2-s2.0-85141664539en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage152en_US
dc.identifier.trdizinid486014en_US
dc.identifier.urihttps://doi.org/10.26650/eor.2021911441
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/486014
dc.identifier.urihttps://hdl.handle.net/11616/92678
dc.identifier.volume55en_US
dc.identifier.wosWOS:000702918900008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIstanbul Univ Press, Istanbul Univ Rectorateen_US
dc.relation.ispartofEuropean Oral Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDirect pulp cappingen_US
dc.subjectreparative dentinen_US
dc.subjectcollagen spongeen_US
dc.subjectBioAggregateen_US
dc.subjectBioAggregate-sponge compositeen_US
dc.titleEvaluation of a collagen-bioaggregate composite scaffold in the repair of sheep pulp tissueen_US
dc.typeConference Objecten_US

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