Salusins, newly identified regulators of hemodynamics and mitogenesis, increase in polycystic ovarian syndrome
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the current study, we aimed to investigate whether serum salusin alpha and beta levels are different in PCOS subjects. Fifty women with PCOS and 50 healthy, age-and body mass index matched controls were included to the prospective cross-sectional study. All subjects underwent venous blood drawing on the early follicular phase after an overnight fasting. Serum salusin alpha and beta levels were measured with EIA, and ELISA respectively. The relationships between serum salusin levels and anthropometric and metabolic parameters were also assessed. Plasma salusin alpha and beta levels were higher in women with PCOS compared to control group. Serum salusin alpha level correlated positively with salusin beta and fasting serum insulin levels. The serum salusin beta levels were correlated positively with HOMA-IR, TG, LDL-C, LH, FSH, and total testosterone levels. Our results indicate that salusins, newly identified regulators of hemodynamics and mitogenesis, are increased within the serum of women with PCOS.
Açıklama
Anahtar Kelimeler
Cardiovascular risk, insulin resistance, PCOS, salusin-alpha, salusin-beta
Kaynak
Gynecological Endocrinology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
29
Sayı
1
