Biological Activities of NHC-Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents

Küçük Resim Yok

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Mdpi

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

N-heterocyclic carbene (NHC) precursors (2a-i), their pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-themed palladium N-heterocyclic carbene complexes (3a-i) and palladium N-heterocyclic triphenylphosphines complexes (4a-i) were synthesized and characterized by elemental analysis and H-1 NMR, C-13 NMR, IR, and LC-MS spectroscopic techniques. The (NHC)Pd(II) complexes 3-4 were tested against MCF7 and MDA-MB-231 cancer cells, Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans microorganisms, Leishmania major promastigotes and amastigotes, Toxoplasma gondii parasites, and Vero cells in vitro. The biological assays indicated that all compounds are highly active against cancer cells, with an IC50 < 1.5 mu g mL(-1). Eight compounds proved antibacterial and antileishmanial activities, while only three compounds had strong antifungal activities against C. albicans. In our conclusion, compounds 3 (b, f, g, and h) and 4b are the most suitable drug candidates for anticancer, antimicrobial, and antiparasitical.

Açıklama

Anahtar Kelimeler

Pd(II)– N-heterocyclic carbene (NHC) complexes, benzimidazolium salts, biological activities, cytotoxicity

Kaynak

Catalysts

WoS Q Değeri

Q2

Scopus Q Değeri

Q2

Cilt

10

Sayı

10

Künye