Biological Activities of NHC-Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents

Basit Öğe Kaydı
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridKhan, Tariq Ayub/0000-0001-6184-5929
dc.authoridAL NASR, IBRAHIM/0000-0003-4690-1050
dc.authoridHamdi, Naceur/0000-0003-0110-9588
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidTouj, Nedra/AAM-2982-2021
dc.authorwosidTouj, Nedra/G-6828-2019
dc.authorwosidNasr, Ibrahim Al/AFP-8105-2022
dc.authorwosidHamdi, Naceur/M-3308-2016
dc.contributor.authorAl Nasr, Ibrahim
dc.contributor.authorTouj, Nedra
dc.contributor.authorKoko, Waleed
dc.contributor.authorKhan, Tariq
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorYasar, Sedat
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:49:00Z
dc.date.available2024-08-04T20:49:00Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractN-heterocyclic carbene (NHC) precursors (2a-i), their pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-themed palladium N-heterocyclic carbene complexes (3a-i) and palladium N-heterocyclic triphenylphosphines complexes (4a-i) were synthesized and characterized by elemental analysis and H-1 NMR, C-13 NMR, IR, and LC-MS spectroscopic techniques. The (NHC)Pd(II) complexes 3-4 were tested against MCF7 and MDA-MB-231 cancer cells, Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans microorganisms, Leishmania major promastigotes and amastigotes, Toxoplasma gondii parasites, and Vero cells in vitro. The biological assays indicated that all compounds are highly active against cancer cells, with an IC50 < 1.5 mu g mL(-1). Eight compounds proved antibacterial and antileishmanial activities, while only three compounds had strong antifungal activities against C. albicans. In our conclusion, compounds 3 (b, f, g, and h) and 4b are the most suitable drug candidates for anticancer, antimicrobial, and antiparasitical.en_US
dc.description.sponsorshipDeanship of Scientific Research, Qassim Universityen_US
dc.description.sponsorshipResearchers would like to thank the Deanship of Scientific Research, Qassim University for funding publication of this project.en_US
dc.identifier.doi10.3390/catal10101190
dc.identifier.issn2073-4344
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85092700333en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/catal10101190
dc.identifier.urihttps://hdl.handle.net/11616/99590
dc.identifier.volume10en_US
dc.identifier.wosWOS:000584126700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCatalystsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPd(II)– N-heterocyclic carbene (NHC) complexesen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectbiological activitiesen_US
dc.subjectcytotoxicityen_US
dc.titleBiological Activities of NHC-Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituentsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu