The Frequency of Subclinical Hypothyroidism in Obese Children and Adolescents and Its Relationship with Metabolic Parameters and Atherogenic Index

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dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authorwosidDundar, Ismail/ABG-2027-2021
dc.authorwosidDundar, Ismail/AAA-2528-2021
dc.contributor.authorDundar, Ismail
dc.contributor.authorAkinci, Aysehan
dc.date.accessioned2024-08-04T20:10:11Z
dc.date.available2024-08-04T20:10:11Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The effect of subclinical hypothyroidism on glucose and lipid metabolism in obese children is controversial. This study aims to compare cardiovascular risk factors in obese patients with or without subclinical hypothyroidism and determine the frequency of subclinical hypothyroidism in obese children and adolescents. Materials and Methods: A total of 1130 obese children and adolescents aged 6-18 years were included in this single-center cross-sectional study. Metabolic parameters such as thyrotropin, free thyroxine, free triiodothyronine, homeostasis model assessment for insulin resistance, atherogenic index, and lipids were evaluated. The patients were divided into two groups-subclinical hypothyroidism group (free thyroxine normal, thyroid-stimulating hormone 5.5-10 mIU/L) (n = 59) and the control group (free thyroxine normal, thyroid-stimulating hormone < 5 mIU/L) (n = 1071). Results: Subclinical hypothyroidism was detected in 59 (5.2%) of 1130 patients. The mean body mass index was similar in both groups. The mean serum insulin, homeostasis model assessment for insulin resistance, triglyceride, atherogenic index of plasma, aspartate aminotransferase, and alanine aminotransferase levels were higher in the subclinical hypothyroidism group, and the mean high-density lipoprotein cholesterol level was lower than the control group (P =.005, P <.001, P =.028, P <.001, P =.001, P <.001, and P =.018, respectively). While a positive correlation was observed between the thyroid-stimulating hormone levels and insulin, homeostasis model assessment for insulin resistance, alanine aminotransferase, triglyceride, and basal cortisol levels, a negative correlation was found between thyroid-stimulating hormone and highdensity lipoprotein cholesterol. Conclusion: Subclinical hypothyroidism can negatively affect the lipid and glucose profile.en_US
dc.identifier.doi10.5152/TurkArchPediatr.2022.21264
dc.identifier.endpage322en_US
dc.identifier.issn2757-6256
dc.identifier.issue3en_US
dc.identifier.pmid35781235en_US
dc.identifier.scopus2-s2.0-85130644579en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage316en_US
dc.identifier.trdizinid524828en_US
dc.identifier.urihttps://doi.org/10.5152/TurkArchPediatr.2022.21264
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/524828
dc.identifier.urihttps://hdl.handle.net/11616/92651
dc.identifier.volume57en_US
dc.identifier.wosWOS:000841885800009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Archives of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsubclinical hypothyroidismen_US
dc.subjectchildhood obesityen_US
dc.subjectdyslipidemiaen_US
dc.subjectinsulin resistanceen_US
dc.subjectatherogenicen_US
dc.subjectindexen_US
dc.titleThe Frequency of Subclinical Hypothyroidism in Obese Children and Adolescents and Its Relationship with Metabolic Parameters and Atherogenic Indexen_US
dc.typeArticleen_US

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