Chronic effects of fluoride in Tuj sheep on serum levels of total protein, albumin, uric acid, and nitric oxide and activities of lactate dehydrogenase and leucine aminopeptidase
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int Soc Fluoride Research
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Twenty healthy yearling Tuj ewe-lambs with a mean body weight of 31 2 kg were divided into two equal groups. Each group of ten sheep was provided with hay and water ad libitum throughout the study. The water for the control group contained 0.49 mg F/L, whereas the water for the experimental group contained 13.8 mg F/L, equivalent for the latter group to an intake of ca. 1.8 mg F/kg bw/day. By the 12(th) week the urinary fluoride concentration in the experimental group had increased from 0.9 ppm at the start to 1.78 ppm, and by the 24(th) week it reached 8 ppm, at which point various serum determinations were made and the study was terminated. In the experimental vs. the control groups the results were as follows: total protein 7.41 +/- 0.03 vs. 7.67 +/- 0.07 g/dL (p<0.01), albumin 3.97 +/- 0.36 vs. 4.72 +/- 0.28 g/dL, nitric oxide 49.90 +/- 3.1 vs. 35.75 +/- 2.7 mu mol/L (p < 0.01), uric acid 0.49 +/- 0.03 vs. 0.29 +/- 0.02 mg/dL (p < 0.001), lactate dehydrogenase (LDH) 676.7 +/- 21 vs. 518 +/- 35 U/L (p < 0.01), and leucine aminopeptidase (LAP) 7.28 +/- 0.5 vs. 6.18 +/- 0.53 U/L. Changes in the albumin level and the LAP activity were not statistically significant. During and at the end of the study the urine fluoride concentration of the control group was unchanged.
Açıklama
Anahtar Kelimeler
albumin, lactate dehydrogenase (LDH), leucine aminopeptidase (LAP), nitric oxide, protein, sheep serum, Tuj sheep, uric acid
Kaynak
Fluoride
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
38
Sayı
1
