Microfluidics-Based Nanoparticle Formulations: Preparation and Evaluation of Protein Delivery Systems
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Polymeric nanoparticles have attracted significant attention due to their potential in drug delivery, material science, and chemistry. In general, the targeted activities of nanoparticles (NPs) are affected by their size and morphology. Microfluidic methods offer precise control over nanoparticle properties, providing better reproducibility and uniformity. This study investigates the effects of microfluidic method parameters on the physicochemical properties and protein delivery potential of synthesized poly(lactic-co-glycolic acid) (PLGA) nanoparticles. The size of the nanoparticles was precisely tuned by varying the flow rate ratios (FRR), total flow rate (TFR), polymer, protein, and surfactant concentrations. Proteins with various molecular weights, including bovine serum albumin (BSA), lysozyme, and aprotinin, were effectively encapsulated, and their drug release kinetics and structural integrity were investigated. By simultaneously evaluating three structurally distinct model proteins within a single microfluidic system, this study provides a comprehensive insight into the role of protein size and charge on nanoparticle formation and release behavior for the first time. This research contributes to the advancement of nanoparticle formulation strategies using microfluidic technology. Microfluidic systems hold great potential for rapid, easy, effective, low-cost, and high-yield NP production.
Açıklama
Anahtar Kelimeler
aprotinin, lysozyme, microfluidics, nanoparticle formulations, protein delivery
Kaynak
Polymers For Advanced Technologies
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
36
Sayı
7
