Microfluidics-Based Nanoparticle Formulations: Preparation and Evaluation of Protein Delivery Systems

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dc.contributor.authorBezelya, Aysenur
dc.contributor.authorKucukturkmen, Berrin
dc.contributor.authorBoncu, Tugba Eren
dc.contributor.authorBozkir, Asuman
dc.date.accessioned2026-04-04T13:37:37Z
dc.date.available2026-04-04T13:37:37Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractPolymeric nanoparticles have attracted significant attention due to their potential in drug delivery, material science, and chemistry. In general, the targeted activities of nanoparticles (NPs) are affected by their size and morphology. Microfluidic methods offer precise control over nanoparticle properties, providing better reproducibility and uniformity. This study investigates the effects of microfluidic method parameters on the physicochemical properties and protein delivery potential of synthesized poly(lactic-co-glycolic acid) (PLGA) nanoparticles. The size of the nanoparticles was precisely tuned by varying the flow rate ratios (FRR), total flow rate (TFR), polymer, protein, and surfactant concentrations. Proteins with various molecular weights, including bovine serum albumin (BSA), lysozyme, and aprotinin, were effectively encapsulated, and their drug release kinetics and structural integrity were investigated. By simultaneously evaluating three structurally distinct model proteins within a single microfluidic system, this study provides a comprehensive insight into the role of protein size and charge on nanoparticle formation and release behavior for the first time. This research contributes to the advancement of nanoparticle formulation strategies using microfluidic technology. Microfluidic systems hold great potential for rapid, easy, effective, low-cost, and high-yield NP production.
dc.description.sponsorshipAnkara Universitesi [TYL-2023-2894]; Ankara University Scientific Research Projects Coordination Unit (AU BAP)
dc.description.sponsorshipThis study was supported by the Ankara University Scientific Research Projects Coordination Unit (AU BAP, Project Code: TYL-2023-2894). The authors are grateful to AU BAP for their support.
dc.identifier.doi10.1002/pat.70250
dc.identifier.issn1042-7147
dc.identifier.issn1099-1581
dc.identifier.issue7
dc.identifier.orcid0009-0002-5300-3726
dc.identifier.scopus2-s2.0-105009700117
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/pat.70250
dc.identifier.urihttps://hdl.handle.net/11616/109945
dc.identifier.volume36
dc.identifier.wosWOS:001519302500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPolymers For Advanced Technologies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectaprotinin
dc.subjectlysozyme
dc.subjectmicrofluidics
dc.subjectnanoparticle formulations
dc.subjectprotein delivery
dc.titleMicrofluidics-Based Nanoparticle Formulations: Preparation and Evaluation of Protein Delivery Systems
dc.typeArticle

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