Evaluation of second-trimester maternal serum betatrophin levels and lipid and carbohydrate metabolism parameters in patients with gestational diabetes mellitus

dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridBULMUŞ, FUNDA GÜLCÜ/0000-0002-2514-4559
dc.authoridAKYOL, ALPASLAN/0000-0001-5089-8961
dc.authoridGURSU, M.Ferit/0000-0003-3552-7315
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidBULMUŞ, FUNDA GÜLCÜ/V-9326-2018
dc.authorwosidAKYOL, ALPASLAN/W-7521-2018
dc.authorwosidgürsu, mehmet/HJZ-1663-2023
dc.authorwosidGURSU, M.Ferit/V-6898-2017
dc.contributor.authorBulmus, Funda Gulcu
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorGursu, Mehmet Ferit
dc.contributor.authorBagci, Helin
dc.contributor.authorKavak, Ebru Celik
dc.contributor.authorAkyol, Alpaslan
dc.date.accessioned2024-08-04T20:10:01Z
dc.date.available2024-08-04T20:10:01Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We investigated the role of betatrophin in the etiopathogenesis of gestational diabetes mellitus (GDM) and its association with lipid and carbohydrate metabolism in patients with GDM and normoglycemic pregnant women. Materials and Methods: A total of 60 patients [30 pregnant women with GDM (study group) and 30 healthy age-, body mass index-, and gestational age-matched pregnant women (control group)] were included in this study. Serum betatrophin, fasting glucose, insulin, glycated hemoglobin A1c (HbA1c), and C-peptide levels, as well as lipid parameters, were measured. Results: Serum betatrophin, fasting glucose, HbA1c, insulin, and C-peptide levels were significantly higher in the GDM group than in the control group (p<0.001, p=0.009, p=0.013, p<0.001, and p<0.001, respectively). Levels of triglycerides and very-low-density lipoprotein cholesterol were significantly higher in the GDM group (p=0.020 and p=0.020, respectively), but total cholesterol and LDL cholesterol levels were similar in the two groups (p=0.810 and p=0.273, respectively). Betatrophin levels in the GDM group were correlated positively with insulin levels (r=0.336, p=0.009) and the homeostatic model assessment of insulin resistance (HOMA-IR) score (r=0.269, p=0.038), and negatively with the C-peptide levels (r=-0.399, p=0.002); they were not correlated with any other glucose or lipid parameters. Multivariate stepwise linear regression analysis demonstrated that insulin levels (beta=0.134, p=0.013) and the HOMA-IR score (beta=0.112, p=0.017) were associated independently with serum betatrophin levels. Conclusion: These results demonstrate that serum betatrophin levels were significantly higher in pregnant women with GDM than in normoglycemic pregnant women. The levels of betatrophin were correlated significantly with insulin resistance parameters, which is a key feature of GDM pathophysiology.en_US
dc.identifier.doi10.4274/tjod.galenos.2020.67026
dc.identifier.endpage33en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue1en_US
dc.identifier.pmid32341827en_US
dc.identifier.scopus2-s2.0-85088988407en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage28en_US
dc.identifier.trdizinid427766en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2020.67026
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/427766
dc.identifier.urihttps://hdl.handle.net/11616/92562
dc.identifier.volume17en_US
dc.identifier.wosWOS:000523674600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBetatrophinen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectinsulin resistanceen_US
dc.titleEvaluation of second-trimester maternal serum betatrophin levels and lipid and carbohydrate metabolism parameters in patients with gestational diabetes mellitusen_US
dc.typeArticleen_US

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