Synthesis and antibacterial activities of new bis-benzimidazoles
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ecv-Editio Cantor Verlag Medizin Naturwissenschaften
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Twenty bis-benzimidazole derivatives were synthesised by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesised were identified by H-1, C-13-NMR, FT-IR and micro analysis. All compounds studied in this work were screened for their in vitro antibacterial activity against standard strains; Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Ten of the compounds were found effective to inhibit the growth of gram-positive bacteria (E. faecalis and S. aureus) at MIC (minimal inhibitory concentration) values between 50-400 mug/ml. Two of the compounds showed MIC values of 200 mug/ml against gram-negative bacteria (E. coli and P aeruginosa).
Açıklama
Anahtar Kelimeler
bis-benzimidazole derivatives, antibacterial activity, in vitro studies, synthesis
Kaynak
Arzneimittel-Forschung-Drug Research
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
54
Sayı
1
