Synthesis and antibacterial activities of new bis-benzimidazoles

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dc.authoridKazaz, Cavit/0000-0002-5249-0895
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidKazaz, Cavit/AGG-7269-2022
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.contributor.authorKüçükbay, H
dc.contributor.authorDurmaz, R
dc.contributor.authorOkuyucu, N
dc.contributor.authorGünal, S
dc.contributor.authorKazaz, C
dc.date.accessioned2024-08-04T20:13:36Z
dc.date.available2024-08-04T20:13:36Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTwenty bis-benzimidazole derivatives were synthesised by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesised were identified by H-1, C-13-NMR, FT-IR and micro analysis. All compounds studied in this work were screened for their in vitro antibacterial activity against standard strains; Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Ten of the compounds were found effective to inhibit the growth of gram-positive bacteria (E. faecalis and S. aureus) at MIC (minimal inhibitory concentration) values between 50-400 mug/ml. Two of the compounds showed MIC values of 200 mug/ml against gram-negative bacteria (E. coli and P aeruginosa).en_US
dc.identifier.endpage68en_US
dc.identifier.issn0004-4172
dc.identifier.issue1en_US
dc.identifier.pmid14979611en_US
dc.identifier.scopus2-s2.0-0347247676en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://hdl.handle.net/11616/93713
dc.identifier.volume54en_US
dc.identifier.wosWOS:000188832700010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung-Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbis-benzimidazole derivatives, antibacterial activity, in vitro studies, synthesisen_US
dc.titleSynthesis and antibacterial activities of new bis-benzimidazolesen_US
dc.typeArticleen_US

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