Detecting the shape differences of the corpus callosum in behçets disease by statistical shape analysis
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to assess the shape differences of the corpus
callosum (CC) in patients with Behc¸et’s disease using statistical
shape analysis (SSA). Additionally, an attempt was made to investigate
the changes in CC size according to disease duration. Twenty-five adults
with clinically diagnosed Behc¸et’s disease and 25 age- and gendermatched
controls were examined by high-resolution structural magnetic
resonance imaging. The data obtained from the coordinate of landmarks
were analyzed with Euclidean distance matrix analysis and a thin-plate
spline analysis. SSA and growth curve models were performed to investigate
group differences and to fit the curves. A significant difference was
determined between CC shape of Behc¸et patients and controls (P ¼
0.006). Based on the analysis, a decrease occurred in the CC size of the
Behc¸et patients as the duration of disease increased. Maximum deformations
were determined in the landmarks of interior notch of the splenium,
inferior tip of the splenium, posterior-most point of the CC, and topmost
point of the CC. Similarly, the landmark of anterior-most point of the CC
was identified as having the minimum deformation. Behc¸et patients had
significantly different CC shapes from control subjects. The results suggest
that SSA is a promising tool for distinguishing Behc¸et patients from
normal subjects, and that it can give useful information to assist clinicians.
Additionally, SSA might be applied to detect shape differences in
anatomical structures that are affected by a broad range of neurological
diseases.
Açıklama
Anahtar Kelimeler
Behçets disease, Corpus callosum, Geometric morphometrics, Growth curve models, Statistical shape analysis
Kaynak
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
WoS Q Değeri
Scopus Q Değeri
Cilt
294
Sayı
Künye
Çolak, C. Ercan, İ. Doğan, M. Turan Özdemir, S. Şener, S. Alkan, A. (2011). Detecting the shape differences of the corpus callosum in behçets disease by statistical shape analysis. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 294:870–874.
