Detecting the shape differences of the corpus callosum in behçets disease by statistical shape analysis

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dc.authorid9217en_US
dc.contributor.authorÇolak, Cemil
dc.contributor.authorErcan, İlker
dc.contributor.authorDoğan, Metin
dc.contributor.authorTuran Özdemir, Senem
dc.contributor.authorŞener, Serpil
dc.contributor.authorAlkan, Alpay
dc.date.accessioned2017-08-21T08:34:14Z
dc.date.available2017-08-21T08:34:14Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to assess the shape differences of the corpus callosum (CC) in patients with Behc¸et’s disease using statistical shape analysis (SSA). Additionally, an attempt was made to investigate the changes in CC size according to disease duration. Twenty-five adults with clinically diagnosed Behc¸et’s disease and 25 age- and gendermatched controls were examined by high-resolution structural magnetic resonance imaging. The data obtained from the coordinate of landmarks were analyzed with Euclidean distance matrix analysis and a thin-plate spline analysis. SSA and growth curve models were performed to investigate group differences and to fit the curves. A significant difference was determined between CC shape of Behc¸et patients and controls (P ¼ 0.006). Based on the analysis, a decrease occurred in the CC size of the Behc¸et patients as the duration of disease increased. Maximum deformations were determined in the landmarks of interior notch of the splenium, inferior tip of the splenium, posterior-most point of the CC, and topmost point of the CC. Similarly, the landmark of anterior-most point of the CC was identified as having the minimum deformation. Behc¸et patients had significantly different CC shapes from control subjects. The results suggest that SSA is a promising tool for distinguishing Behc¸et patients from normal subjects, and that it can give useful information to assist clinicians. Additionally, SSA might be applied to detect shape differences in anatomical structures that are affected by a broad range of neurological diseases.en_US
dc.identifier.citationÇolak, C. Ercan, İ. Doğan, M. Turan Özdemir, S. Şener, S. Alkan, A. (2011). Detecting the shape differences of the corpus callosum in behçets disease by statistical shape analysis. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 294:870–874.en_US
dc.identifier.doi10.1002/ar.21373en_US
dc.identifier.endpage874en_US
dc.identifier.startpage870en_US
dc.identifier.urihttps://hdl.handle.net/11616/7645
dc.identifier.volume294en_US
dc.language.isoenen_US
dc.publisherThe Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biologyen_US
dc.relation.ispartofThe Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehçets diseaseen_US
dc.subjectCorpus callosumen_US
dc.subjectGeometric morphometricsen_US
dc.subjectGrowth curve modelsen_US
dc.subjectStatistical shape analysisen_US
dc.titleDetecting the shape differences of the corpus callosum in behçets disease by statistical shape analysisen_US
dc.typeArticleen_US

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