Differential diagnosis of the granulomatous appendicitis: Retrospective analysis of 16 cases

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dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridBAYINDIR, Yasar/0000-0003-3930-774X
dc.authorwosidYAKUPOGULLARI, YUSUF/F-3966-2011
dc.authorwosidSARICI, KEMAL BARIŞ/ABI-4356-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidKoc, Cemalettin/B-6430-2018
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.contributor.authorAkbulut, Sami
dc.contributor.authorKoc, Cemalettin
dc.contributor.authorSarici, Kemal Baris
dc.contributor.authorSamdanci, Emine
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorBayindir, Yasar
dc.date.accessioned2024-08-04T20:10:04Z
dc.date.available2024-08-04T20:10:04Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: This study aims to present the usability of real-time polymerase chain reaction (PCR) and interferon-gamma release assay (IGRA) in the differential diagnosis of granulomatous appendicitis (GAp), especially in areas where tuberculosis (TB) is endemic. METHODS: Sixteen patients underwent appendectomy with presumed diagnosis of acute appendicitis were retrospectively analyzed for histopathological diagnosis of GAp. Real-time PCR method was used to show the whether presence of DNA of the tubercle bacilli in paraffin-embedded tissue blocks. IGRA test was used to investigate whether tubercle bacilli-specific interferon gamma was present in peripheral blood. RESULTS: Sixteen patients (male: 10 female: 6) aged between 21 and 82 years were included in this study. All patients had acute appendicitis and three of them also had appendiceal perforation. Histopathologically, necrotizing granulomatous inflammation was detected in all appendectomy specimens. Acid-fast bacilli were not detected in any of the pathology slides stained with Ehrlich-Ziehl-Neelsen. Real-time PCR was studied in paraffin-embedded tissue blocks of all patients with GAp, but the TB bacilli DNA was amplified in only three patients. IGRA test was studied in peripheral blood samples of 12 patients with GAp and results were as follows: negative (n=9), positive (n=2) and indeterminate (n=1). CONCLUSION: We believe that the use of anamnesis, histopathological findings, tissue PCR, blood IGRA and clinical findings together are important for differential diagnosis of GAp, especially where TB is endemic. We also suggest that all appendectomy specimens should be sent to the laboratory for histopathological evaluation even if specimens appear macroscopically normal.en_US
dc.identifier.doi10.14744/tjtes.2020.98582
dc.identifier.endpage221en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue2en_US
dc.identifier.pmid33630300en_US
dc.identifier.scopus2-s2.0-85102096725en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage214en_US
dc.identifier.trdizinid504633en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.98582
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/504633
dc.identifier.urihttps://hdl.handle.net/11616/92586
dc.identifier.volume27en_US
dc.identifier.wosWOS:000642343300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute appendictisen_US
dc.subjectgranulomatous appendicitisen_US
dc.subjectinterferon-gamma release assayen_US
dc.subjectperforated appendicitisen_US
dc.subjectpolymerase chain reactionen_US
dc.titleDifferential diagnosis of the granulomatous appendicitis: Retrospective analysis of 16 casesen_US
dc.typeArticleen_US

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