Erythrocyte catalase activities in alcohol consumption, medications and some diseases
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Dosyalar
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: Katalaz (CAT) hidrojen peroksidin parçalanmasında katalitik rol oynarken, peroksidin hidrojen donörüne okside edilmesinde peroksidik bir rol oynar. Bu çalışmada alkol tüketimi, ilaçlar ve hastalıkların eritrosit katalaz aktivitesi üzerine etkisini araştırmak amaçlanmıştır. Bu amaç için denekler 3 farklı gruba ayrıldılar; 1- alkol alan ve almayan 2-ilaç alan ve almayan 3- lösemi, hepatit, diabetes mellitus ve kardiyak hastalıkları olanlar. Katalaz aktivitesi Aebi metodu ile ölçüldü. Hemoglobin düzeyleri Olympus AU-600 otoanalizörüyle tayin edildi. MCH, HCT, MCHC, MCV ve RBC gibi hematolojik değerler Coulter STKS cihazıyla çalışıldı. İlaç alan ve almayanların katalaz aktivitesinde bir farklılık gözlenmedi (3155 ± 1039 k/g Hb ve 3051 ± 956 k/g Hb, p>.0,05). Sağlıklı kişilerdeki ile lösemililerin, kalp hastalarının, hepatitlilerin ve diabetes mellitusluların katalaz aktiviteleri arasında fark bulunamadı. Alkol ile enzim aktivitesi belirgin bir şekilde arttı. CAT aktiviteleri alkol almayanlarda 3059 ± 958 k/g Hb ve alkol alanlarda 3644 ± 984 k/g Hb olarak bulundu (p<0,03).
Abstract: Catalase (CAT) has a catalytic role in the decomposition of hydrogen peroxide (H2O2) and a peroxidic role in which the peroxide is utilized to oxidize a range of H donors. The objective of the present study was to determine whether alcohol consumption, medications, and diseases have an effect in the erythrocyte on CAT activity or not. For this purpose, the subjects were divided into three different groups with their unique criteria: 1-alcoholic and nonalcoholic, 2- subjects under medication and no medication, and 3- subjects with leukemia, hepatitis, diabetes mellitus, and heart diseases. CAT activity was measured by the method of Aebi. The hemoglobin levels were determined by Olympus AU-600 auto analyzer. Hematological parameters such as MCH HCT, MCHC, MCV, and RBC were studied by Coulter STKS instrument. There was no effect of medication on CAT activity 3155
Abstract: Catalase (CAT) has a catalytic role in the decomposition of hydrogen peroxide (H2O2) and a peroxidic role in which the peroxide is utilized to oxidize a range of H donors. The objective of the present study was to determine whether alcohol consumption, medications, and diseases have an effect in the erythrocyte on CAT activity or not. For this purpose, the subjects were divided into three different groups with their unique criteria: 1-alcoholic and nonalcoholic, 2- subjects under medication and no medication, and 3- subjects with leukemia, hepatitis, diabetes mellitus, and heart diseases. CAT activity was measured by the method of Aebi. The hemoglobin levels were determined by Olympus AU-600 auto analyzer. Hematological parameters such as MCH HCT, MCHC, MCV, and RBC were studied by Coulter STKS instrument. There was no effect of medication on CAT activity 3155
Açıklama
Anahtar Kelimeler
Kaynak
İnönü Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
1
Künye
TEMEL İ,ÖZEROL E,BAY A,ÇIĞLI A,AKYOL Ö (2002). Erythrocyte catalase activities in alcohol consumption, medications and some diseases. İnönü Üniversitesi Tıp Fakültesi Dergisi, 9(1), 11 - 14.
