Trend in initial presenting features of type 1 diabetes mellitus over a 24 year period in Turkey: a retrospective analysis of 814 cases

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dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authoridÇamtosun, Emine/0000-0002-8144-4409
dc.authoridDundar, Ismail/0000-0003-1468-6405;
dc.authorwosidDundar, Ismail/AAA-2528-2021
dc.authorwosidÇamtosun, Emine/AAE-3945-2020
dc.authorwosidDundar, Ismail/ABG-2027-2021
dc.authorwosidÇiftci, Nurdan/GNM-8116-2022
dc.contributor.authorDundar, Ismail
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorCamtosun, Emine
dc.contributor.authorCiftci, Nurdan
dc.contributor.authorKayas, Leman
dc.contributor.authorNalbantoglu, Ozlem
dc.date.accessioned2024-08-04T20:10:10Z
dc.date.available2024-08-04T20:10:10Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The study aim was to examine changes in trends of presenting features during the diagnosis of patients followed up with newly diagnosed Type 1 diabetes mellitus (T1DM) over the past 24 years. Methods. The study was retrospective. Patients with a diagnosis of T1D between the years of 1996-2019 were included. Patients diagnosed in the first half of the period comprised Period I, and those from the second half comprised Period II. Patient data were extracted from medical records and included gender distribution, year of diagnosis, age at diagnosis, duration of symptoms, type of admission, frequency of diabetic ketoacidosis (DKA) and biochemical parameters. Subsequently, temporal changes in trends of these parameters were sought. Results. For the whole cohort the gender distribution was equal; 404 (49.6%) were girls and 410 (50.4%) were boys. Mean age at diagnosis was 8.5 +/- 4.2 years and age groupings at presentation were: 23.2% (n = 189) aged 0-4; 39.2% (n = 319) aged 5-9; 27.5% (n = 224) aged 10-13; 10.1% (n= 82) aged 14-18. At presentation 72 (12.7%) had hyperglycemia, 230 (40.6%) had diabetic ketosis, and 264 (46.6%) had DKA. In those with DKA, mild DKA was found in 103 (39.0%), moderate DKA in 81 (30.6%), and severe DKA in 80 (30.3%). While the frequency of DKA was 54.9% between 1996 and 2007 (Period I), this significantly decreased to 44.4% between 2008 and 2019 (Period II). Girls and boys had a similar rate of T1DM, and this did not change over time. Three peak ages of diagnosis were evident; 5-7, 8-10, 12-14 years of age. Conclusions. The frequency of DKA decreased and the frequency of admission with hyperglycemia and ketosis increased during the study period, which may have repercussions for mortality and morbidity rates and aid in improved treatment outcomes.en_US
dc.identifier.doi10.24953/turkjped.2020.3580
dc.identifier.endpage48en_US
dc.identifier.issn0041-4301
dc.identifier.issue1en_US
dc.identifier.pmid35286029en_US
dc.identifier.scopus2-s2.0-85126411612en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage40en_US
dc.identifier.trdizinid1138010en_US
dc.identifier.urihttps://doi.org/10.24953/turkjped.2020.3580
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1138010
dc.identifier.urihttps://hdl.handle.net/11616/92635
dc.identifier.volume64en_US
dc.identifier.wosWOS:000819914600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttype I diabetesen_US
dc.subjectdiabetic ketoacidosisen_US
dc.subjectchildhooden_US
dc.subjecttrenden_US
dc.titleTrend in initial presenting features of type 1 diabetes mellitus over a 24 year period in Turkey: a retrospective analysis of 814 casesen_US
dc.typeArticleen_US

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