Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis a randomized double blind placebo controlled trial
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Arthroscopy
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose To compare the effectiveness of intraarticular
(IA) multiple and single platelet-rich plasma (PRP) injections
as well as hyaluronic acid (HA) injections in different
stages of osteoarthritis (OA) of the knee.
Methods A total of 162 patients with different stages of
knee OA were randomly divided into four groups receiving
3 IA doses of PRP, one dose of PRP, one dose of HA
or a saline injection (control). Then, each group was subdivided
into two groups: early OA (Kellgren–Lawrence grade
0 with cartilage degeneration or grade I–III) and advanced
OA (Kellgren–Lawrence grade IV). The patients were
evaluated before the injection and at the 6-month followups
using the EuroQol visual analogue scale (EQ-VAS)
and International Knee Documentation Committee (IKDC)
subjective scores. Adverse events and patient satisfaction
were recorded.
Results There was a statistically significant improvement
in the IKDC and EQ-VAS scores in all the treatment
groups compared with the control group. The knee scores
of patients treated with three PRP injections were significantly
better than those patients of the other groups. There
was no significant difference in the scores of patients injected with one dose of PRP or HA. In the early OA subgroups,
significantly better clinical results were achieved in
the patients treated with three PRP injections, but there was
no significant difference in the clinical results of patients
with advanced OA among the treatment groups.
Conclusion The clinical results of this study suggest
IA PRP and HA treatment for all stages of knee OA. For
patients with early OA, multiple (3) PRP injections are
useful in achieving better clinical results. For patients
with advanced OA, multiple injections do not significantly
improve the results of patients in any group.
Açıklama
Anahtar Kelimeler
Hyaluronic acid, Intraarticular injection, Knee osteoarthritis, Platelet-rich plasma
Kaynak
Arthroscopy
WoS Q Değeri
Scopus Q Değeri
Cilt
25
Sayı
3
Künye
Görmeli, G. Görmeli, C. A. Ataoğlu, B. Çolak, C. Aslantürk, O. Ertem, K. (2015). Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis a randomized double blind placebo controlled trial. Arthroscopy. 25,3; 958-965.
