Early relaparotomy in recipients after living donor liver transplantation: causes, risk factors, and consequences

Basit Öğe Kaydı
dc.contributor.authorBarut, Bora
dc.contributor.authorCeylan, Cengiz
dc.contributor.authorZengin, Akile
dc.contributor.authorGuzel, Mehmet
dc.contributor.authorDalda, Yasin
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2026-04-04T13:30:42Z
dc.date.available2026-04-04T13:30:42Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground/aim: Despite advancements in surgical methodologies and the extensive perioperative and postoperative care administered to recipients, the prevalence of complications requiring early relaparotomy following living donor liver transplantation (LDLT) remains persistent. This study sought to analyze the determinants influencing relaparotomy occurrences in the initial 30 days following LDLT. Additionally, it was aimed to evaluate the impact of early laparotomy on both graft and patient survival within this distinct patient cohort. Materials and methods: The study encompassed recipients (n = 535) aged 18 years and older who underwent primary LDLT at our institution from January 2019 to December 2021. Exclusion criteria involved patients necessitating early retransplantation. Early relaparotomy was specified as surgical intervention within the initial 30 days following LDLT. Results: The study enrolled a total of 535 patients, among whom 85 (15.9%) underwent early relaparotomy. The median age of the patients was 54 (range: 41-60) years, with a predominant male representation (66.2%). Univariate analysis comparing the laparotomy and nonrelaparotomy groups revealed statistically significant differences in the creatinine (p = 0.043) and sodium (p = 0.025) levels, graft side (p < 0.001), etiology (p = 0.005), and blood loss (p = 0.012). In the multivariate analysis, creatinine (p = 0.039; OR = 1.668; 95% CI = 1.027-2.709) and left lobe graft (p < 0.0001; OR = 3.611; 95% CI = 1.960-6.652) emerged as independent risk factors for relaparotomy. Conclusion: The primary causes of early relaparotomy following LDLT include postoperative bleeding, biliary leakage, and vascular complications. Preoperative elevation in creatinine and sodium levels, the presence of Budd-Chiari syndrome, utilization of a left lobe graft, and intraoperative blood loss are identified as risk factors associated with early relaparotomy after LDLT. Patients undergoing early relaparotomy exhibit inferior survival rates compared to those who do not.
dc.identifier.doi10.55730/1300-0144.5863
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5
dc.identifier.orcid0000-0002-0701-8399
dc.identifier.pmid39473745
dc.identifier.scopus2-s2.0-85208162461
dc.identifier.scopusqualityQ2
dc.identifier.trdizinid1276698
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5863
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1276698
dc.identifier.urihttps://hdl.handle.net/11616/108317
dc.identifier.volume54
dc.identifier.wosWOS:001342117900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectEarly
dc.subjectrelaparotomy
dc.subjectrecipients
dc.subjectliving donor
dc.subjectliver transplantation
dc.titleEarly relaparotomy in recipients after living donor liver transplantation: causes, risk factors, and consequences
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu