?-Glucan ameliorates cisplatin-induced oxidative and histological damage in kidney and liver of rats
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We investigated the effects of beta-glucan (beta g) on kidney and liver damage caused by cisplatin (CP), an antineoplastic agent widely used to treat many types of cancer, in a rat model. The side effects of CP in many tissues and organs limit its usage. beta g is a natural polysaccharide that is an effective free radical scavenger. A total of 28 rats were randomly divided into four groups. Group 1 was a non-intervention control, only feed and water were given. Group 2 was administered 7 mg/kg CP in a single dose. Group 3 was administered 50 mg/kg beta g orally for 14 days. Group 4 was administered beta g for 14 days, following a single dose of CP. At the end of the experiment, kidney and liver tissues were evaluated biochemically and histopathologically. Increased thiobarbituric acid-reactive substances (TBARS) levels, as well as decreased catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and reduced glutathione (GSH) levels, as well as histological damage, were noted in both the kidney and liver tissues of the CP group. However, beta g treatment prevented the oxidative and histopathological effects of CP. The study demonstrates the protective efficacy of beta g against CP-induced kidney and liver damage through the effect of its antioxidant properties.
Açıklama
Anahtar Kelimeler
Beta-glucan, cisplatin, kidney injury, liver injury, oxidative stress
Kaynak
Biotechnic & Histochemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
99
Sayı
2
