?-Glucan ameliorates cisplatin-induced oxidative and histological damage in kidney and liver of rats

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dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.contributor.authorKaya, Kursat
dc.contributor.authorCiftci, O.
dc.contributor.authorTurkmen, N. Basak
dc.contributor.authorTaslidere, A.
dc.contributor.authorGul, C. C.
dc.date.accessioned2024-08-04T20:55:08Z
dc.date.available2024-08-04T20:55:08Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the effects of beta-glucan (beta g) on kidney and liver damage caused by cisplatin (CP), an antineoplastic agent widely used to treat many types of cancer, in a rat model. The side effects of CP in many tissues and organs limit its usage. beta g is a natural polysaccharide that is an effective free radical scavenger. A total of 28 rats were randomly divided into four groups. Group 1 was a non-intervention control, only feed and water were given. Group 2 was administered 7 mg/kg CP in a single dose. Group 3 was administered 50 mg/kg beta g orally for 14 days. Group 4 was administered beta g for 14 days, following a single dose of CP. At the end of the experiment, kidney and liver tissues were evaluated biochemically and histopathologically. Increased thiobarbituric acid-reactive substances (TBARS) levels, as well as decreased catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and reduced glutathione (GSH) levels, as well as histological damage, were noted in both the kidney and liver tissues of the CP group. However, beta g treatment prevented the oxidative and histopathological effects of CP. The study demonstrates the protective efficacy of beta g against CP-induced kidney and liver damage through the effect of its antioxidant properties.en_US
dc.identifier.doi10.1080/10520295.2024.2320626
dc.identifier.endpage100en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid38444353en_US
dc.identifier.scopus2-s2.0-85186880219en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2024.2320626
dc.identifier.urihttps://hdl.handle.net/11616/101862
dc.identifier.volume99en_US
dc.identifier.wosWOS:001180808900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBeta-glucanen_US
dc.subjectcisplatinen_US
dc.subjectkidney injuryen_US
dc.subjectliver injuryen_US
dc.subjectoxidative stressen_US
dc.title?-Glucan ameliorates cisplatin-induced oxidative and histological damage in kidney and liver of ratsen_US
dc.typeArticleen_US

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