THE EFFECTS OF MELATONIN, FLUOXETINE AND THEIR COMBINATIONS ON STRESS-INDUCED BEHAVIORAL AND COGNITIVE IMPAIRMENTS IN MICE

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dc.authorscopusid57908630200
dc.authorscopusid6604007154
dc.authorscopusid55217729300
dc.authorscopusid56868482500
dc.authorscopusid6506486079
dc.contributor.authorİncı Çamçı M.
dc.contributor.authorErdi?nç M.
dc.contributor.authorKelle İ.
dc.contributor.authorUyar E.
dc.contributor.authorErdınç L.
dc.date.accessioned2024-08-04T20:03:45Z
dc.date.available2024-08-04T20:03:45Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Melatonin (Mlt) is a hormone with antidepressant and antioxidant features. It is well known that Mlt protects brain cells from reactive oxygen species and that the brain's high oxygen consumption and lipid content make it particularly vulnerable to oxidative stress caused by prolonged stress. This study aims to investigate the effects of melatonin, fluoxetine (Flx) and their combinations on emotional memory, depression, and anxiety-like behavioral changes induced by immobilization (Imb) stress. Material and Method: 48 male Balb/c mice were divided into eight groups: Cnt (control), Imb, Imb+Mlt, Imb+Flx, Imb+Mlt+Flx, Mlt, Flx and Mlt+Flx. For seven days in a row, the mice underwent daily immobilization stress for 6 hours. Mice were treated with Mlt (10 mg/kg) and Flx (20 mg/kg) or saline 30 min prior to the immobilization stress procedure. All animals were subjected to behavioral tests; forced swimming test (FST), open field test (OFT), elevated plus maze (EPM), passive avoidance test (PAT), and hot plate (HP) test. After all behavioral tests, brain tissues were obtained for malondialdehyde (MDA) level analysis. Result and Discussion: OFT test data showed the time spent in the central zone and the number of entrances to the central area were lower in the Imb group compared to the Cnt group; these were higher in the Imb+Flx, Imb+Mlt, Imb+Mlt+Flx groups compared to the Imb group. Also, according to the data obtained from FST, immobile time was significantly higher in the Imb group compared to the Cnt group, and it was lower in the Imb+Flx, Imb+Mlt, Imb+Mlt+Flx groups compared to the Imb group. Besides, it was demonstrated that the emotional memory index was statistically higher in the Imb group compared to the Cnt group, and the increasing of memory index returned to normal in the Imb+Mlt and Imb+Mlt+Flx groups with PAT. Furthermore, lipid peroxidation level, which increased in the Imb group, decreased significantly in the Imb+Flx, Imb+Mlt, and Imb+Mlt+Flx groups. As a result, it was observed that melatonin has antidepressant, anxiolytic, antioxidant effects and normalized emotional memory. Also, melatonin, fluoxetine, and their combinations exert similar effects in the present study. © 2022 University of Ankara. All rights reserved.en_US
dc.description.sponsorshipDicle Üniversitesi: TIP.16.011en_US
dc.description.sponsorshipThe authors are grateful to Dicle University Scientific Research Projects (Project No: TIP.16.011) for financial support.en_US
dc.identifier.doi10.33483/jfpau.1153861
dc.identifier.issn2564-6524
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85145317104en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.trdizinid1155472en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1153861
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1155472
dc.identifier.urihttps://hdl.handle.net/11616/92043
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnxietyen_US
dc.subjectdepressionen_US
dc.subjectemotional memoryen_US
dc.subjectmelatoninen_US
dc.subjectstressen_US
dc.titleTHE EFFECTS OF MELATONIN, FLUOXETINE AND THEIR COMBINATIONS ON STRESS-INDUCED BEHAVIORAL AND COGNITIVE IMPAIRMENTS IN MICEen_US
dc.title.alternativeFARELERDE STRESİN NEDEN OLDUĞU DAVRANIŞSAL VE KOGNİTİF BOZUKLUKLARA MELATONİN, FLUOKSETİN VE KOMBİNASYONLARININ ETKİSİen_US
dc.typeArticleen_US

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