RELATIONSHIPS BETWEEN PARKINSON'S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorEkmekyapar, Tuba
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorDemirtas, Yasemin
dc.contributor.authorAltinayar, Sibel
dc.date.accessioned2024-08-04T20:10:09Z
dc.date.available2024-08-04T20:10:09Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Parkinson's disease dementia is an important condition that worsens the quality of life in approximately 30% of parkinson disease patients. Vitamin D deficiency and brain-derived neurotrophic factor have been implicated in the pathogenesis of alzheimer type dementia, parkinson's disease, and many neurodegenerative diseases. The aim of this study was to investigate the relationship between cognitive impairment and 25-hydroxy vitamin D and brain-derived neurotrophic factor levels in parkinson's disease dementia patients. Materials and Method: 25-hydroxy vitamin D and brain-derived neurotrophic factor serum levels were evaluated in patients with parkinson's disease dementia (n = 63) and healthy controls (n = 33). Brain-derived neurotrophic factor and vitamin D levels were examined using one sample t-tests, and multiple comparisons among independent groups were done using ANOVA post hoc Tukey's test analysis. Wechsler Memory Scale and Mini-Mental State Examination were used to evaluate the cognitive functions of the groups. The disease levels of the patients were determined using the Hoehn and Yahr scale and the Unified Parkinson's Disease Rating Scale. Results: There was a significant negative correlation between the worsening of dementia and vitamin D levels (p = 0.009). However, there were significant negative correlations between the unified parkinson's disease rating scale daily living activity and Hoehn and Yahr scales and vitamin D levels. No significant relationship was found between brain-derived neurotrophic factor and parkinson's disease dementia (p = 0.983). Conclusions: Vitamin D deficiency plays a role in cognitive loss in parkinson's disease dementia. Vitamin D replacement can be used in dementia support treatment.en_US
dc.description.sponsorshipInonu University Scientific Project Unit [2016-75]en_US
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Project Unit with project number 2016-75.en_US
dc.identifier.doi10.31086/tjgeri.2021.238
dc.identifier.endpage415en_US
dc.identifier.issn1304-2947
dc.identifier.issn1307-9948
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85116328883en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage407en_US
dc.identifier.trdizinid529320en_US
dc.identifier.urihttps://doi.org/10.31086/tjgeri.2021.238
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/529320
dc.identifier.urihttps://hdl.handle.net/11616/92612
dc.identifier.volume24en_US
dc.identifier.wosWOS:000702235500013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGunes Kitabevi Ltd Stien_US
dc.relation.ispartofTurkish Journal of Geriatrics-Turk Geriatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParkinson Diseaseen_US
dc.subjectDementiaen_US
dc.subjectVitamin Den_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.titleRELATIONSHIPS BETWEEN PARKINSON'S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELSen_US
dc.typeArticleen_US

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