Silica nanoparticle synthesis by experimental design for drug and gene delivery applications

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dc.authoridŞahin, Adem/0000-0002-3996-2931
dc.authoridUltav, Gozde/0000-0001-5582-3766
dc.authorwosidŞahin, Adem/IYT-0077-2023
dc.authorwosidUltav, Gözde/JPK-6247-2023
dc.contributor.authorUltav, Gozde
dc.contributor.authorTonbul, Hayrettin
dc.contributor.authorSahin, Adem
dc.contributor.authorCapan, Yilmaz
dc.date.accessioned2024-08-04T20:10:19Z
dc.date.available2024-08-04T20:10:19Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSilica nanoparticles (SNPs) are one of the most researched drug/gene delivery platforms due to their easy and cheap production. Their toxicity depends on the nanoparticle characteristics like particle size or shape. It is well known that the smaller nanoparticles have a better cellular uptake potential. For this reason, in this study, we synthesized SNPs with a particle size of around 100 nm via an experimental design method that combines Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS) with Taguchi design to optimize more than one response. After the optimization, average particle size, particle size distribution, zeta potential, and particle morphology of validated SNPs were analyzed. The cytotoxicity studies were performed on fibroblast cells (L929) for 48 and 72 hours. Results show that obtained nanoparticles were spherical-shaped with a size of around 100 nm and had good biocompatibility.en_US
dc.description.sponsorshipHacettepe University Coordinatorship of Scientific Research Projects [THD-2016-12890]en_US
dc.description.sponsorshipAcknowledgments: SEM was performed in Middle East Technical University Central Laboratory. A part of this study was supported by the Hacettepe University Coordinatorship of Scientific Research Projects with the project code THD-2016-12890. Special thanks to Esra Pezik for her support.en_US
dc.identifier.doi10.29228/jrp.243
dc.identifier.endpage22en_US
dc.identifier.issn2630-6344
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85147820024en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage12en_US
dc.identifier.trdizinid1177223en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.243
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177223
dc.identifier.urihttps://hdl.handle.net/11616/92700
dc.identifier.volume27en_US
dc.identifier.wosWOS:000992608700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTOPSIS based Taguchi Designen_US
dc.subjectdesign of experimenten_US
dc.subjectsilica nanoparticlesen_US
dc.subjectdrug deliveryen_US
dc.subjectgene deliveryen_US
dc.titleSilica nanoparticle synthesis by experimental design for drug and gene delivery applicationsen_US
dc.typeArticleen_US

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