Effects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids in rats: a peroxisomal perspective

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dc.authorscopusid56922077000
dc.authorscopusid7801691639
dc.authorscopusid55890995200
dc.authorscopusid23488669300
dc.authorscopusid6604070029
dc.authorscopusid7004559930
dc.authorscopusid6602634150
dc.contributor.authorOtlu H.G.
dc.contributor.authorUğur Y.
dc.contributor.authorYıldız A.
dc.contributor.authorErdoğan S.
dc.contributor.authorYoloğlu S.
dc.contributor.authorVardı N.
dc.contributor.authorGüldür T.
dc.date.accessioned2024-08-04T20:02:19Z
dc.date.available2024-08-04T20:02:19Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Lipidomics studies of sleep restriction, which is known to be associated with circadian perturbations, revealed alterations in some plasma phospholipid levels including plasmalogens which are partly synthesized in liver peroxisomes. To this end it was aimed to investigate effects of various conditions known to cause circadian rhythm disturbances on various peroxisomal parameters and to compare those effects with that of fenofibrate, a peroxisome proliferator-activated receptor alpha agonist. Materials and methods: Plasmalogens and some fatty acids in erythrocyte lysates were analyzed by GC. Peroxisomal metabolites including very long chain fatty acids as well as phytanic and pristanic acids in plasma were measured by GC-MS. Immunohistological analyses by catalase antibodies were conducted on liver sections. Results: All the conditions tested exhibited increased catalase immunoreactivity in liver sections compared to that of controls. Both calorie restriction, time-restricted feeding, as well as fenofibrate treatment exhibited lower C18:0 plasmalogen contents of erythrocyte lysates. As plasmalogens are known to be synthesized by peroxisomes, the present results suggest that the peroxisomal lipid content in membranes might be affected by conditions co-occuring with circadian perturbations. Conclusion: Shared effects of conditions associated with circadian rhythm disturbances and peroxisomal induction by fenofibrate on erythrocyte membrane lipids might indicate a link between them. © 2024, Pamukkale University. All rights reserved.en_US
dc.description.sponsorshipInönü Üniversitesi: TDK-2017-601en_US
dc.description.sponsorshipThis research received funding support from Inonu University, Scientific Research Unit [contract TDK-2017-601]. We thank Nobel Pharmaceutical Industry and Trade Company for providing fenofibrate. We appreciate help of SYNLAB Türkiye Laboratory for VLCFA, phytanic and pristanic acid analyses. This manuscript also has been represented in FEBS congress as a poster, 3-8 July 2021; Ljubljana, Slovenia. A preprint version of this article has been published with DOI:10.21203/rs.3.rs-68404/v1.en_US
dc.identifier.doi10.31362/patd.1327736
dc.identifier.endpage98en_US
dc.identifier.issn1309-9833
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85187889019en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage87en_US
dc.identifier.trdizinid1219209en_US
dc.identifier.urihttps://doi.org/10.31362/patd.1327736
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1219209
dc.identifier.urihttps://hdl.handle.net/11616/91595
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherPamukkale Universityen_US
dc.relation.ispartofPamukkale Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalorie restrictionen_US
dc.subjectcircadian rhythmen_US
dc.subjectfenofibrateen_US
dc.subjectperoxisomeen_US
dc.subjectplasmalogenen_US
dc.titleEffects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids in rats: a peroxisomal perspectiveen_US
dc.title.alternativeSıçanlarda sirkadiyen ritim bozuklukları ile ilgili çeşitli koşulların plazma ve eritrosit lipidleri üzerindeki etkileri: peroksizomal bir bakış açısıen_US
dc.typeArticleen_US

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