Pan-İmmune Inflammatory Index Predicts Increased Epicardial Adipose Tissue in Prediabetics

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dc.contributor.authorYildirim, Aslihan Mete
dc.contributor.authorBayramoglu, Adil
dc.date.accessioned2026-04-04T13:35:16Z
dc.date.available2026-04-04T13:35:16Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectives Prediabetes is a global health problem due to its adverse effects on glucose metabolism. Prediabetes also triggers many inflammatory mechanisms that can lead to vascular and molecular damage of various systems and organs. Pan-immun inflammatory level (PIV) is a new biomarker that is considered with many ianflammatory conditions. Epicardial adipose tissue (EAT) is also considered an endocrine organ, which has been shown in many studies to be related to inflammation. There are studies showing that inflammatory parameters and epicardial adipose tissue are affected in diabetic patients. However, no such research has been conducted on prediabetic patients. In this study, we aimed to investigate inflammatory parameters and their relationship with epicardial adipose tissue in prediabetic patients. Methods 220 patients with prediabetes and 96 healthy controls were compared in the study regarding laboratory and demographic parameters and echocardiographic evaluations. Results There were significant differences between the groups in various parameters including epicardial adipose tissue (p < 0.001), NLR (p = 0.011); SII (p = 0.003); PIV (p < 0.001), In prediabetic patients, epicardial adipose tissue was correlated with PIV (r: 0.490; p < 0.001), SII (r: 0.248; p < 0.001), and NLR (r: 0.234; p: 0.001). PIV and presence of prediabetes were independent predictors of epicardial adipose tissue. Conclusion In this study, we observed that the presence of prediabetes is associated with EAT thickness. Again, in this patient group, we thought that PIV could be an easily obtainable parameter that could indicate an increase in EAT thickness.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK)
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK).
dc.identifier.doi10.1007/s44411-025-00021-y
dc.identifier.endpage327
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue3
dc.identifier.orcid0000-0002-6523-9130
dc.identifier.scopus2-s2.0-85217655418
dc.identifier.scopusqualityQ2
dc.identifier.startpage322
dc.identifier.urihttps://doi.org/10.1007/s44411-025-00021-y
dc.identifier.urihttps://hdl.handle.net/11616/109730
dc.identifier.volume126
dc.identifier.wosWOS:001465550900011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectPrediabetes
dc.subjectPan-immun inflammatory value
dc.subjectEpicardial adipose tissue
dc.subjectInflammatory markers
dc.titlePan-İmmune Inflammatory Index Predicts Increased Epicardial Adipose Tissue in Prediabetics
dc.typeArticle

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