Analysis of urine biomarkers for early determination of acute kidney injury in non septic and non asphyxiated critically ill preterm neonates
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
The Journal of Maternal-Fetal & Neonatal Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: We designed the present study to test the hypothesis that urinary biomarkers might
predict acute kidney injury (AKI) development in non-septic and non-asphyxiated critically ill
preterm infants. We evaluated urine (u) sistatin–C (uCys-C), kidney injury molecule–1 (uKIM–1)
and neutrophil gelatinase associate lipocaline (uNGAL) as markers of AKI.
Methods: Sixty-four preterm infants with gestational age between 28 and 32 weeks were
included in this study. Biomarkers were measured on day of life (DOL) 1, 3, and 7.
Results: uNGAL levels in the AKI group were significantly higher than in no-AKI group on DOL 1,
3 and 7 (p ¼ 0.016, p ¼ 0.007 and p ¼ 0.0014, respectively).
Conclusions: uNGAL is sensitive, early, and noninvasive AKI biomarkers, increasing significantly
in non-septic and non-asphyxiated critically ill preterm neonates.
Açıklama
Anahtar Kelimeler
Acute kidney injury, Kidney injury molecule–1, Neutrophil gelatinase associate lipocaline, Preterm infants, Sistatin–C, Urine
Kaynak
The Journal of Maternal-Fetal & Neonatal Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
30
Sayı
3
Künye
Karadağ, A. Elmas, T. Tabel, Y. Özdemir, R. Otlu, H. G. (2016). Analysis of urine biomarkers for early determination of acute kidney injury in non septic and non asphyxiated critically ill preterm neonates. The Journal of Maternal-Fetal & Neonatal Medicine, 30(3), 302–308.
