HBV viral load and tumor and non-tumor factors in patients with HBV-associated HCC

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dc.contributor.authorAtaman, Engin
dc.contributor.authorHarputluoglu, Murat
dc.contributor.authorCarr, Brian Irving
dc.contributor.authorGozukara, Harika
dc.contributor.authorInce, Volkan
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:56:07Z
dc.date.available2024-08-04T20:56:07Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aim: Several tumor and non-tumor factors affect the prognosis of hepatocellular carcinoma (HCC) patients. This study aimed to investigate the effects of hepatitis B virus (HBV) viral load on tumor and non-tumor factors in patients with HBV-associated HCC. Materials and Methods: Patients with hepatitis B and HCC who presented Transplantation Institute, were included in our study. Patients were divided into two groups according to the presence or absence of HBV-DNA, and it was determined whether there were differences between these two groups with respect to tumor and non-tumor parameters. Results: Comparison of serum alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), hepatitis B surface antigen (HBsAg), and C-reactive protein (CRP) levels between HBV-DNA negative and positive patients showed significant differences (respectively p<0.01, p<0.01, p<0.05, and p<0.05). A major finding was a very significant difference between the two patient groups in terms of portal vein invasion (PVI) and venous invasion (p<0.001 and p<0.01, respectively). However, there was no significant difference in metastasis or lymph node involvement between HBV-DNA negative and positive patients. Conclusion: Our findings suggest that HBV viral load plays an important role in PVI in HCC patients, and there is a significant relationship between HBV viral load and inflammation.en_US
dc.identifier.doi10.14744/hf.2023.2023.0038
dc.identifier.endpage76en_US
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue2en_US
dc.identifier.pmid38487738en_US
dc.identifier.scopus2-s2.0-85196706859en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.14744/hf.2023.2023.0038
dc.identifier.urihttps://hdl.handle.net/11616/102075
dc.identifier.volume5en_US
dc.identifier.wosWOS:001182619800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Ben_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectHBV-DNAen_US
dc.titleHBV viral load and tumor and non-tumor factors in patients with HBV-associated HCCen_US
dc.typeArticleen_US

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