Investigating biological activity potential of Plantago lanceolata L. In healing of skin wounds by a preclinical research

Basit Öğe Kaydı
dc.contributor.authorKuranel, E.
dc.contributor.authorKüpeli Akkol, E.
dc.contributor.authorSüntar, I.
dc.contributor.authorGürsoy, Ş.
dc.contributor.authorKeleş, H.
dc.contributor.authorAktay, G.
dc.date.accessioned2019-09-25T06:36:46Z
dc.date.available2019-09-25T06:36:46Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPlantago lanceolata L. has been used for wound healing in Turkish traditional medicine. In the present study the wound healing and anti-inflammatory effects of the aqueous and methanol extract of P. lanceolata were investigated. In vivo excision and incision wound models were applied on mice and rats for the evaluation of the wound healing effect of P. lanceolata. Inhibitory effect of the extracts on acetic acid-induced increase in capillary permeability was assessed by using Whittle Method. Moreover, the levels of thiobarbituric acid reactive substances (TBARs), glutathione (GSH), total thiols (TSH), hydroxyproline (HP), and tissue trace elements (Zn+2 and Cu+2) were analysed. The aqueous extract of P. lanceolata was found to have wound healing activity in both incision and excision wound models. The results obtained from histopathological analysis also supported the data. Significant anti-inflammatory activity was also detected for both extracts. P. lanceolata significantly reduced the levels of TBARs which is one of the indicators of oxidative stress on the wounded tissue and increased the levels of GSH, TSH and HP. Additionally, P. lanceolata was found to have capacity to increase the levels of tissue Zn+2and Cu+2, both of which are important indicators in the process of wound healing and collagen synthesis. The results indicated that P. lanceolata which is used in the treatment of wounds in addition to many illnesses in traditional medicine and is rich in terms of flavanoids has a powerful antioxidant effect and so it has a positive assistance in healing process. More advanced studies are needed to illuminate the mechanism accurately. © 2016, Turkish Pharmacists Association. All rights reserved.en_US
dc.identifier.citationKuranel, E. Küpeli Akkol, E. Süntar, I. Gürsoy, Ş. Keleş, H . Aktay, G. (2016). Investigating biological activity potential of Plantago lanceolata L. In healing of skin wounds by a preclinical research.Cilt:13. Sayı:2. 135- 144 ss.en_US
dc.identifier.endpage144en_US
dc.identifier.issn1304-530X
dc.identifier.issn2148-6247
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84979966649en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage135en_US
dc.identifier.trdizinid203608en_US
dc.identifier.urihttps://hdl.handle.net/11616/14266
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/203608
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Associationen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectGlutathioneen_US
dc.subjectPlantaginaceaeen_US
dc.subjectPlantago lanceolataen_US
dc.subjectTiobarbituric aciden_US
dc.subjectWound healingen_US
dc.titleInvestigating biological activity potential of Plantago lanceolata L. In healing of skin wounds by a preclinical researchen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu