Determination of gentamicin by using square wave anodic stripping voltammetry with poly (?-cyclodextrin-p-toluene sulfonic acid) modified glassy carbon electrode
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, an effective electrochemical method based on modified glassy carbon electrode was developed for the determination of gentamicin. Firstly, the poly beta-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode as gentamicin selective electrode was prepared by electropolymerization technique. In situ electropolymerization of beta-cyclodextrin and p-toluene sulfonic acid was conducted on bare glassy carbon electrode by controlled potential cycling. Characterization of the prepared poly beta-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode was performed using cyclic voltammetry and electrochemical impedance spectroscopy. Then, the effects of various parameters were investigated using square wave anodic stripping voltammetry in citrate buffer containing 4.0 mmol L-1 gentamicin. The calibration graph plotted over the range of 0.06-4.0 mmol L-1 gentamicin concentration showed high linearity. Correlation coefficient, detection limit and quantitation limit were obtained from the calibration graph as 0.9999, 3.7 mu mol L-1 and 12.4 mu mol L-1, respectively. According to these results, it is seen that the prepared poly beta-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode can be successfully used for the determination of gentamicin in many pharmacological, medical and biochemical applications.
Açıklama
Anahtar Kelimeler
Gentamicin, beta-cyclodextrin, p-toluene sulfonic acid, Glassy carbon electrode, Sensor
Kaynak
Polymer Bulletin
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
81
Sayı
7
