Insular volume reduction in young male schizophrenia patients

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dc.authoridERBAY, MEHMET FATİH/0000-0002-1596-3147
dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authorwosidERBAY, MEHMET FATİH/ABI-2942-2020
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.contributor.authorErbay, Mehmet Fatih
dc.contributor.authorKartalci, Sukru
dc.date.accessioned2024-08-04T20:10:02Z
dc.date.available2024-08-04T20:10:02Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Recent developments in neuroimaging have advanced the understanding of biological mechanisms underlying schizophrenia. Structural and functional abnormalities of the insular cortex have been reported in schizophrenia patients. Many studies have demonstrated that insula volume is lower in schizophrenia patients than healthy individuals. The present study aimed to compare insula volumes of young male schizophrenia patients with that of age-matched young healthy male subjects to eliminate age and gender bias. Methods: Twenty-three male schizophrenia patients meeting DSM-5 diagnostic criteria, who were at the age of 18-40 years, and age-matched 25 healthy male subjects were included into the study. All patients magnetic resonance imaging (MRI) procedure was completed. Insula volume of schizophrenia patients and healthy male volunteers was calculated using MRICloud method. Disease severity was assessed using Positive and Negative Symptom Scale (PANSS). Results: Volumes of both the left and the right insula were significantly lower in the patient group vs. the control group. Moreover, a positive correlation was determined between the right insula volume and the scores of positive symptom severity scale. Conclusion: Decreased insular volume is not a specific marker, but it may be a general marker regarding psychopathology. However, investigating whether the diagnostic specificity of insular cortex abnormalities in psychopathologies will be the focus of future studies.en_US
dc.identifier.doi10.5455/apd.85006
dc.identifier.endpage584en_US
dc.identifier.issn1302-6631
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85095423852en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage579en_US
dc.identifier.trdizinid426184en_US
dc.identifier.urihttps://doi.org/10.5455/apd.85006
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/426184
dc.identifier.urihttps://hdl.handle.net/11616/92570
dc.identifier.volume21en_US
dc.identifier.wosWOS:000584374800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectschizophreniaen_US
dc.subjectinsular cortexen_US
dc.subjectMRIClouden_US
dc.subjectneuroimagingen_US
dc.titleInsular volume reduction in young male schizophrenia patientsen_US
dc.typeArticleen_US

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