Intrathecal baclofen: Does tolerance occur?
Küçük Resim Yok
Tarih
1993
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Concern over the development of tolerance in patients on continuous intrathecal baclofen therapy has arisen as this new form of treatment for spasticity has gained wider use. We have studied time-dose relationships in 18 spinal cord injured patients who have undergone intrathecal baclofen infusion pump implantation since February 1988 in our facility. Our data show that there was a significant increase in baclofen dosage needed to control spasticity during the first 12 months post implantation. After 12 months, however, no significant change in dosage requirement was detected. In addition, there was no significant difference between completely and incompletely spinal cord injured patients with regard to both the initial dose and the tolerance trend. © 1993 International Medical Society of Paraplegia.
Açıklama
Anahtar Kelimeler
Intrathecal baclofen, Spasticity, Spinal cord injury, Tolerance
Kaynak
Paraplegia
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
31
Sayı
8
