Intrathecal baclofen: Does tolerance occur?

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dc.authorscopusid7004407667
dc.authorscopusid7003263395
dc.authorscopusid7005038010
dc.authorscopusid57189392391
dc.authorscopusid35616020100
dc.contributor.authorAkman M.N.
dc.contributor.authorLoubser P.G.
dc.contributor.authorDonovan W.H.
dc.contributor.authorO’Neill M.E.
dc.contributor.authorRossi C.D.
dc.date.accessioned2024-08-04T19:59:12Z
dc.date.available2024-08-04T19:59:12Z
dc.date.issued1993
dc.departmentİnönü Üniversitesien_US
dc.description.abstractConcern over the development of tolerance in patients on continuous intrathecal baclofen therapy has arisen as this new form of treatment for spasticity has gained wider use. We have studied time-dose relationships in 18 spinal cord injured patients who have undergone intrathecal baclofen infusion pump implantation since February 1988 in our facility. Our data show that there was a significant increase in baclofen dosage needed to control spasticity during the first 12 months post implantation. After 12 months, however, no significant change in dosage requirement was detected. In addition, there was no significant difference between completely and incompletely spinal cord injured patients with regard to both the initial dose and the tolerance trend. © 1993 International Medical Society of Paraplegia.en_US
dc.description.sponsorshipH133N00016-91; National Institute on Disability and Rehabilitation Research, NIDRRen_US
dc.description.sponsorshipThis work was supported in part by a grant from the National Institute on Disability and Rehabilitation Research, US Department of Education, Grant Number H133N00016-91.en_US
dc.identifier.doi10.1038/sc.1993.84
dc.identifier.endpage520en_US
dc.identifier.issn0031-1758
dc.identifier.issue8en_US
dc.identifier.pmid8414636en_US
dc.identifier.scopus2-s2.0-0027199266en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage516en_US
dc.identifier.urihttps://doi.org/10.1038/sc.1993.84
dc.identifier.urihttps://hdl.handle.net/11616/90452
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofParaplegiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntrathecal baclofenen_US
dc.subjectSpasticityen_US
dc.subjectSpinal cord injuryen_US
dc.subjectToleranceen_US
dc.titleIntrathecal baclofen: Does tolerance occur?en_US
dc.typeArticleen_US

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