Cerebrospinal fluid nitric oxide level changes in preeclampsia
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The purpose of this study was to determine the level of nitric oxide (NO) metabolites, nitrite and nitrate in human cerebrospinal fluid (CSF) and serum and to assess whether there is any relationship among CSF, serum nitrate-nitrite levels and preeclampsia. Study design: Twenty-one preeclamptic and 27 healthy pregnant women as control group who underwent cesarean section (C/S) were included in the study. Before administering local anesthetic for spinal anesthesia, 2 ml CSF and 4 ml venous blood sample were taken. CSF and serum total nitrite, direct nitrite and nitrate levels were determined spectrophotometrically. Results: CSF total nitrite, direct nitrite and nitrate levels were significantly different between the two groups (21.00 +/- 1.68, 8.28 +/- 0.89 and 12.71 +/- 1.08 mumol/l, respectively versus 15.53 +/- 1.49, 5.57 +/- 0.39 and 9.96 +/- 1.45 mumol/l, respectively, P < 0.05). Significantly higher serum nitrate level was found (31.84 +/- 2.31 mumol/l) in the control group compared to the preeclamptic group serum nitrate level (25.06 +/- 2.02 mumol/l). Statistical comparisons were performed by the Mann-Whitney U-test. Conclusion: CSF-NO is significantly higher but serum NO is lower in preeclamptic group compared with control group may suggest independent regulation of NO in the two compartments. The determination of CSF-NO metabolites could be useful to clarify whether increased NO production is predominantly associated with poor perfusion of the brain in preeclampsia. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Açıklama
5th World Congress of Perinatal Medicine -- SEP 23-27, 2001 -- BARCELONA, SPAIN
Anahtar Kelimeler
nitric oxide, preeclampsia, cerebrospinal fluid
Kaynak
European Journal of Obstetrics Gynecology and Reproductive Biology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
111
Sayı
2
