Cerebrospinal fluid nitric oxide level changes in preeclampsia

Basit Öğe Kaydı
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorCelik, O
dc.contributor.authorHascalik, S
dc.contributor.authorTurkoz, Y
dc.contributor.authorHascalik, M
dc.contributor.authorGokdeniz, R
dc.date.accessioned2024-08-04T20:13:28Z
dc.date.available2024-08-04T20:13:28Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description5th World Congress of Perinatal Medicine -- SEP 23-27, 2001 -- BARCELONA, SPAINen_US
dc.description.abstractObjective: The purpose of this study was to determine the level of nitric oxide (NO) metabolites, nitrite and nitrate in human cerebrospinal fluid (CSF) and serum and to assess whether there is any relationship among CSF, serum nitrate-nitrite levels and preeclampsia. Study design: Twenty-one preeclamptic and 27 healthy pregnant women as control group who underwent cesarean section (C/S) were included in the study. Before administering local anesthetic for spinal anesthesia, 2 ml CSF and 4 ml venous blood sample were taken. CSF and serum total nitrite, direct nitrite and nitrate levels were determined spectrophotometrically. Results: CSF total nitrite, direct nitrite and nitrate levels were significantly different between the two groups (21.00 +/- 1.68, 8.28 +/- 0.89 and 12.71 +/- 1.08 mumol/l, respectively versus 15.53 +/- 1.49, 5.57 +/- 0.39 and 9.96 +/- 1.45 mumol/l, respectively, P < 0.05). Significantly higher serum nitrate level was found (31.84 +/- 2.31 mumol/l) in the control group compared to the preeclamptic group serum nitrate level (25.06 +/- 2.02 mumol/l). Statistical comparisons were performed by the Mann-Whitney U-test. Conclusion: CSF-NO is significantly higher but serum NO is lower in preeclamptic group compared with control group may suggest independent regulation of NO in the two compartments. The determination of CSF-NO metabolites could be useful to clarify whether increased NO production is predominantly associated with poor perfusion of the brain in preeclampsia. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipWorld Assoc Perinatal Meden_US
dc.identifier.doi10.1016/S0301-2115(03)00193-3
dc.identifier.endpage145en_US
dc.identifier.issn0301-2115
dc.identifier.issue2en_US
dc.identifier.pmid14597241en_US
dc.identifier.scopus2-s2.0-0242302312en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1016/S0301-2115(03)00193-3
dc.identifier.urihttps://hdl.handle.net/11616/93646
dc.identifier.volume111en_US
dc.identifier.wosWOS:000186600400005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnitric oxideen_US
dc.subjectpreeclampsiaen_US
dc.subjectcerebrospinal fluiden_US
dc.titleCerebrospinal fluid nitric oxide level changes in preeclampsiaen_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu