Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivatives

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dc.authorscopusid57211807059
dc.authorscopusid23478552500
dc.authorscopusid8832688300
dc.authorscopusid16039658300
dc.authorscopusid6506842056
dc.authorscopusid56151726700
dc.contributor.authorTekin Z.
dc.contributor.authorTekeli Y.
dc.contributor.authorKüçükbay Z.
dc.contributor.authorLolak N.
dc.contributor.authorYapar G.
dc.contributor.authorAkocak S.
dc.date.accessioned2024-08-04T20:03:34Z
dc.date.available2024-08-04T20:03:34Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHerein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3(a-l), were freshly re-synthesized by the reaction of bis-aldehydes with substituted hydrazide derivatives since these compounds previously showed potent aldose reductase inhibition properties. The obtained compounds were tested for their potential antibacterial and antioxidant activities. In the present study, four different bacterial strains were used, including Gram-positive (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212) and Gram-negative (Pseudomonas aeruginosa ATCC 10231, Escherichia coli ATCC 25912). On the other hand, the antioxidant capacities of freshly re-synthesized bis-hydrazone substituted isovanilline derivatives were determined by using several antioxidant methods, including DPPH free radical scanvenging, TEAC cupric reducing (CUPRAC) and metal chelating activity methods. Several lead molecules were discovered as a potential bacterial inhibitors against S. aureus and E. coli bacterial strains. More specifically, compounds 3g (R=-H) and 3j (R=-4Cl) showed great inhibition properties against E. coli bacterial strains by having MIC values of 1.56 and 6.25 µg/mL, respectively. Moreover, none of the compounds showed potent antioxidant activity against tested methods with respect to compared standards. © 2023, Turkish Chemical Society. All rights reserved.en_US
dc.description.sponsorship33467en_US
dc.description.sponsorshipThis work was partially funded by the Istanbul Technical University Grants Commission for a research grant (Project Grant No: 33467).en_US
dc.identifier.doi10.18596/jotcsa.1196335
dc.identifier.endpage442en_US
dc.identifier.issn2149-0120
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85153948578en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage435en_US
dc.identifier.trdizinid1178202en_US
dc.identifier.urihttps://doi.org/10.18596/jotcsa.1196335
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1178202
dc.identifier.urihttps://hdl.handle.net/11616/91932
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Chemical Societyen_US
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntioxidanten_US
dc.subjectHydrazoneen_US
dc.subjectIsovanillinen_US
dc.titleAntibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivativesen_US
dc.typeArticleen_US

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