Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats

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dc.authoridSelçuk, Engin Burak/0000-0001-8484-0223
dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridAydoğan, Nilay/0000-0002-5510-7804
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authorwosidSelçuk, Engin Burak/AAR-7556-2020
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidAydoğan, Nilay/ABH-9450-2020
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.contributor.authorHarputluoglu, Murat Muhsin Muhip
dc.contributor.authorTemel, Ismail
dc.contributor.authorDemirel, Ulvi
dc.contributor.authorSeckin, Yuksel
dc.contributor.authorAladag, Murat
dc.contributor.authorOtlu, Baris
dc.contributor.authorKaradag, Nese
dc.date.accessioned2024-08-04T20:09:52Z
dc.date.available2024-08-04T20:09:52Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamide-induced liver failure in rats. Materials and Methods: Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide daily for 2 days. In group 3 (n=8), the thioacetami de+methylprednisolone group, treatment with methylprednisolone (30 mg/kg intraperitoneal) was commenced 48 h before the first dose of thioacetamide. In group 4 (n=8), the methylprednisolone group, the rats received only methylprednisolone (30 mg/kg intraperitoneal). Results: Serious hepatic and intestinal oxidative damage and high bacterial translocation frequencies were observed in the thioacetamide group compared with those of the controls. Bacterial translocation frequency in the thioacetamide+methylprednisolone group was significantly lower than that in the thioacetamide group (p<0.05). Intestinal thiobarbituric acid-reactive substances and myeloperoxidase levels and tissue damage scores for the intestines in the thioacetamide+methylprednisolone group were lower than those in the thioacetamide group (p<0.01, p<0.01, and p<0.0001, respectively). Conclusion: Our findings suggest that methylprednisolone reduces bacterial translocation by preventing intestinal oxidative damage in this model of acute liver failure in rats.en_US
dc.identifier.doi10.5152/tjg.2017.1775
dc.identifier.endpage400en_US
dc.identifier.issn1300-4948
dc.identifier.issn2148-5607
dc.identifier.issue5en_US
dc.identifier.pmid28776498en_US
dc.identifier.scopus2-s2.0-85029789622en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage394en_US
dc.identifier.trdizinid232859en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2017.1775
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/232859
dc.identifier.urihttps://hdl.handle.net/11616/92482
dc.identifier.volume28en_US
dc.identifier.wosWOS:000411468300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethylprednisoloneen_US
dc.subjectliver failureen_US
dc.subjectbacterial translocationen_US
dc.titleMethylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in ratsen_US
dc.typeArticleen_US

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