Vitreous vascular endothelial growth factor level during gestation
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Heidelberg
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
To evaluate the vitreous VEGF level alterations and its correlation with its plasma level if any, in gestation. The blood and vitreous sampling procedures were performed before, during (20-23 days of gestation), and after gestation (2 months after birth) from seven White New Zealand rabbits. Blood samples were centrifuged then supernatants and vitreous samples were stored at -80A degrees C until assay. Measurements of serum and vitreous VEGF(165) were done by ELISA. The median plasma and vitreous VEGF(165) concentrations were 36.61 pg/ml (range 19.17-40.30), 14.92 pg/ml (range 8.95-15.20); 58.30 pg/ml (range 32.60-11.53), 20.51 pg/ml (range 11.94-21.26); and 35.30 pg/ml (range 27.30-39.60), 13.05 pg/ml (range 9.33-16.04) before, during and after gestation, respectively. Both the plasma and the vitreous VEGF(165) concentration during gestational period were significantly higher than pre-gestational period (P = 0.028, P = 0.018) and post-gestational period (P = 0.043, P = 0.028). The intravitreal VEGF(165) concentrations appeared to correlate with plasma VEGF(165) levels (r = 0.940, P = 0.002) only in the gestational period. Vitreous VEGF levels increase in positive correlation with plasma VEGF during pregnancy. Further prospective studies are needed to support this finding.
Açıklama
Anahtar Kelimeler
VEGF, Gestation, Vitreous, Plasma, Level
Kaynak
Archives of Gynecology and Obstetrics
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
281
Sayı
3
