Vitreous vascular endothelial growth factor level during gestation

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridturkcuoglu, peykan/0000-0002-9750-6213
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidturkcuoglu, peykan/GQB-2596-2022
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorTurkcuoglu, Peykan
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorTasar, Ahmet
dc.date.accessioned2024-08-04T20:32:22Z
dc.date.available2024-08-04T20:32:22Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo evaluate the vitreous VEGF level alterations and its correlation with its plasma level if any, in gestation. The blood and vitreous sampling procedures were performed before, during (20-23 days of gestation), and after gestation (2 months after birth) from seven White New Zealand rabbits. Blood samples were centrifuged then supernatants and vitreous samples were stored at -80A degrees C until assay. Measurements of serum and vitreous VEGF(165) were done by ELISA. The median plasma and vitreous VEGF(165) concentrations were 36.61 pg/ml (range 19.17-40.30), 14.92 pg/ml (range 8.95-15.20); 58.30 pg/ml (range 32.60-11.53), 20.51 pg/ml (range 11.94-21.26); and 35.30 pg/ml (range 27.30-39.60), 13.05 pg/ml (range 9.33-16.04) before, during and after gestation, respectively. Both the plasma and the vitreous VEGF(165) concentration during gestational period were significantly higher than pre-gestational period (P = 0.028, P = 0.018) and post-gestational period (P = 0.043, P = 0.028). The intravitreal VEGF(165) concentrations appeared to correlate with plasma VEGF(165) levels (r = 0.940, P = 0.002) only in the gestational period. Vitreous VEGF levels increase in positive correlation with plasma VEGF during pregnancy. Further prospective studies are needed to support this finding.en_US
dc.identifier.doi10.1007/s00404-009-1144-7
dc.identifier.endpage421en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3en_US
dc.identifier.pmid19521711en_US
dc.identifier.scopus2-s2.0-77950629407en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage417en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-009-1144-7
dc.identifier.urihttps://hdl.handle.net/11616/95018
dc.identifier.volume281en_US
dc.identifier.wosWOS:000274199100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVEGFen_US
dc.subjectGestationen_US
dc.subjectVitreousen_US
dc.subjectPlasmaen_US
dc.subjectLevelen_US
dc.titleVitreous vascular endothelial growth factor level during gestationen_US
dc.typeArticleen_US

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