Hepatitis E Infection in Solid Organ Transplant Recipients in Turkey
dc.authorid | Aysin, Murat/0000-0003-4068-5860 | |
dc.authorid | Sayıner, Ayca Arzu/0000-0001-6750-2353 | |
dc.authorid | Zeytinoglu, Aysin/0000-0003-4174-9539 | |
dc.authorid | Otlu, Baris/0000-0002-6220-0521 | |
dc.authorwosid | Colak, Dilek/C-7162-2016 | |
dc.authorwosid | Aysin, Murat/HRD-9483-2023 | |
dc.authorwosid | Sayıner, Ayca Arzu/P-2220-2019 | |
dc.authorwosid | Zeytinoglu, Aysin/HZI-3677-2023 | |
dc.contributor.author | Ogut, Seval | |
dc.contributor.author | Sayiner, Ayca Arzu | |
dc.contributor.author | Otlu, Baris | |
dc.contributor.author | Bozdayi, Gulendam | |
dc.contributor.author | Zeytinoglu, Aysin | |
dc.contributor.author | Aksaray, Sebahat | |
dc.contributor.author | Colak, Dilek | |
dc.date.accessioned | 2024-08-04T20:10:09Z | |
dc.date.available | 2024-08-04T20:10:09Z | |
dc.date.issued | 2022 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | Background: Hepatitis E virus is a re-emerging pathogen with an increase in human cases that can lead to chronic infection in immunosuppressed patients. Turkey is located between Asia and Europe, 2 regions with distinct epidemiological and clinical features of hepatitis E virus infection. This multicenter cross-sectional study aimed to investigate the prevalence of hepatitis E virus infection in liver and kidney transplant recipients in Turkey and to determine the role of possible transmission factors. Methods: A total of 485 plasma samples of solid organ recipients were collected from 7 transplantation centers in Turkey. Samples were tested for anti-hepatitis E virus immunoglobin M, immunoglobin G, and hepatitis E virus ribonucleic acid. Water- and food-related risk factors were evaluated by a questionnaire. Results: Samples of 300 kidney and 185 liver recipients were collected. Hepatitis E virus ribonucleic acid was tested in 472 samples and none were positive. Anti-hepatitis E virus immunoglobin G and immunoglobin M were detected in 84 (17.3%) and 3 (0.6%) patients, respectively. Seropositivity was associated with older age, male gender, being a liver recipient, and being infected with hepatitis B virus and/or hepatitis C virus. None of the patients under the age of 30 were seropositive. Hepatitis E virus immunoglobin G prevalence was higher in the Central East and Southeast Anatolia. Eating raw meat was the only independent variable associated with hepatitis E virus seropositivity. Conclusion: This is the first prevalence study of hepatitis E virus infection in solid organ recipients in Turkey. Anti-hepatitis E virus immunoglobin G prevalence was 17.3% which was higher than the previously reported rate in blood donors. Seropositivity was significantly higher in liver recipients. Despite the high antibody prevalence, none of the patients were viremic. | en_US |
dc.description.sponsorship | TUBITAK (The Scientific and Technological Research Council of Turkey) [216S904]; Dokuz Eylul University Scientific Research Coordination Unit [KB.SAG.035] | en_US |
dc.description.sponsorship | This study was funded by TUBITAK (The Scientific and Technological Research Council of Turkey) under grant number 216S904 and Dokuz Eylul University Scientific Research Coordination Unit (project number: 2017.KB.SAG.035). | en_US |
dc.identifier.doi | 10.5152/tjg.2021.21071 | |
dc.identifier.endpage | 73 | en_US |
dc.identifier.issn | 2148-5607 | |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 35040790 | en_US |
dc.identifier.scopus | 2-s2.0-85123651138 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 68 | en_US |
dc.identifier.trdizinid | 523825 | en_US |
dc.identifier.uri | https://doi.org/10.5152/tjg.2021.21071 | |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/523825 | |
dc.identifier.uri | https://hdl.handle.net/11616/92623 | |
dc.identifier.volume | 33 | en_US |
dc.identifier.wos | WOS:000744581000009 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | TR-Dizin | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Aves | en_US |
dc.relation.ispartof | Turkish Journal of Gastroenterology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hepatitis antibodies | en_US |
dc.subject | hepatitis E virus | en_US |
dc.subject | kidney transplantation | en_US |
dc.subject | liver transplantation | en_US |
dc.subject | organ transplantation | en_US |
dc.title | Hepatitis E Infection in Solid Organ Transplant Recipients in Turkey | en_US |
dc.type | Article | en_US |