Does apocynin increase liver regeneration in the partial hepatectomy model?

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dc.authoridKose, Adem/0000-0002-1853-1243
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authorwosidKose, Adem/AAD-1226-2020
dc.authorwosidKANAT, BURHAN/GYD-4490-2022
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.contributor.authorBilgic, Yilmaz
dc.contributor.authorKanat, Burhan Hakan
dc.contributor.authorOzhan, Onural
dc.contributor.authorYildiz, Azibe
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:10:21Z
dc.date.available2024-08-04T20:10:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats.Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has been found in glutathione peroxidase, total nitrite, catalase, oxidative stress index, total antioxidant and total oxidant status between sham and hepatectomy groups. A significant difference has been achieved between hepatectomy and posthepatectomy-Apocynin in terms of glutathione peroxidase and oxidative stress index. Total antioxidant status, oxidative stress index, and total oxidant status were significantly different only between the sham and the hepatectomy groups. Statistical differences were found between sham and hepatectomy groups and between hepatectomy and pre+post-hepatectomy-Apocynin groups in terms of serum glutathione, malondialdehyde, total nitrite, and L-Arginine. There were significant differences between the sham and hepatectomy groups, between hepatectomy and posthepatectomy-apocynin groups, between posthepatctomy-apocynin and pre+posthepatectomy-apocynin groups in terms of sinusoidal dilatation, intracytoplasmic vacuolization and glycogen loss (p < 0.001), in all histopathologic parameters except sinusoidal dilatation (p < 0.05). However, significant Ki-67 increases have been elaborated in hepatectomy, posthepatectomy-apocynin, and pre+posthepatectomy-apocynin groups compared to sham group (p < 0.001), in pre+posthepatectomy apocynin group compared to hepatectomy and posthepatectomy-apocynin groups (p < 0.001). Conclusion: Histopathology, immunohistochemistry, and biochemistry results of this study revealed that apocynin has a protective effect on enhancing liver regeneration in partial hepatectomy cases in rats.en_US
dc.description.sponsorshipInouml;nuuml; University, Scientific Research Projects Coordination Unit [2016/191]en_US
dc.description.sponsorshipFunding The project was financially supported by Inonu University, Scientific Research Projects Coordination Unit (project no: 2016/191) .en_US
dc.identifier.doi10.55730/1300-0144.5627
dc.identifier.endpage658en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid37476910en_US
dc.identifier.scopus2-s2.0-85163682874en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage647en_US
dc.identifier.trdizinid1190925en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5627
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1190925
dc.identifier.urihttps://hdl.handle.net/11616/92726
dc.identifier.volume53en_US
dc.identifier.wosWOS:001022334700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectapocyninen_US
dc.subjecthepatectomyen_US
dc.subjectliver regenerationen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.titleDoes apocynin increase liver regeneration in the partial hepatectomy model?en_US
dc.typeArticleen_US

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