Evaluation of Early Postoperative Neurological Complications Following Living Donor Liver Transplantation

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dc.contributor.authorOtan, Emrah
dc.contributor.authorAydın, Cemalettin
dc.contributor.authorYonder, Hüseyin
dc.contributor.authorKayaalp, Cüneyt
dc.contributor.authorKaplan, Yüksel
dc.contributor.authorYılmaz, Sezai
dc.date.accessioned2020-06-01T05:46:33Z
dc.date.available2020-06-01T05:46:33Z
dc.date.issued2015-03
dc.departmentİnönü Üniversitesien_US
dc.descriptionNOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY Volume: 52 Issue: 1 Pages: 15-18en_US
dc.description.abstractIntroduction: Liver transplantation is one of the best treatment options for end-stage liver disease. In Turkey, living donor liver transplantation (LDLT) is performed more frequently than cadaveric transplantation, because organ donation is unpopular in our country. Neurological complications contribute to poor postoperative outcomes after liver transplantation. In the present study, we aimed to evaluate the outcomes of LDLT patients in whom such complications developed early during postoperative follow-up in the intensive care unit. Methods: Of 217 LDLTs performed between August 2011 and August 2012, neurology consultations were arranged for 29 patients (13.36%) because of development of new-onset neurological symptoms and/or findings in patients with neurologically uneventful preoperative histories. We retrospectively collected data on age, gender, primary disease, Model for End-Stage Liver Disease (MELD) score, and postoperative hospitalization duration of those who survived. The indications for neurological consultation and diagnoses were categorized into acute confusion/encephalopathy, epileptic seizures, leukoencephalopathy, and focal neurological deficits. The immunosuppressive treatment regimens prescribed were also considered. The outcomes of the 2 groups (with and without neurological complications) were compared. Results: The mean patient age was 44.52 +/- 16.24 years, and males predominated (65.5%, n=19). Acute confusion/encephalopathy was the most frequent complication (62.1%, n=18), followed by epileptic seizures (27.6%, n=8), cerebrovascular disease (6.9%, n=2), and leukoencephalopathy (3.4%, n=1). Statistically significant between-group differences in age (44.5 +/- 16.2 vs. 34.33 +/- 20.98 years; p<0.001), and proportions of patients with a disease of viral etiology (55.17% vs. 35.63%, p<0.05), were evident. Mortality was significantly higher in the group with neurological complications (65.5% vs. 37.32%, p<0.05). The duration of postoperative hospitalization was also significantly longer in this group (29.80 +/- 15.04 vs. 10.00 +/- 5.47 days; p<0.05). Conclusion: Mortality was significantly higher and the duration of postoperative hospitalization significantly longer in LDLT patients with new-onset neurological complications than in those without such complications.en_US
dc.identifier.citationOtan, E., Aydin, C., Yonder, H., Kayaalp, C., Kaplan, Y., Yilmaz, S. Evaluation of Early Postoperative Neurological Complications Following Living Donor Liver Transplantation (2015). NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRYen_US
dc.identifier.doi10.5152/npa.2015.7226en_US
dc.identifier.endpage18en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue1en_US
dc.identifier.pmid28360669en_US
dc.identifier.scopus2-s2.0-84926627624en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage15en_US
dc.identifier.trdizinid196476en_US
dc.identifier.urihttps://doi.org/10.5152/npa.2015.7226
dc.identifier.urihttps://hdl.handle.net/11616/15603
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/196476
dc.identifier.volume52en_US
dc.identifier.wosWOS:000351851100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGALENOS YAYINCILIKen_US
dc.relation.ispartofNöropsikiyatri Arşivien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver transplantationen_US
dc.subjectNeurological complicationen_US
dc.subjectEncephalopathyen_US
dc.subjectİmmunosuppressionen_US
dc.titleEvaluation of Early Postoperative Neurological Complications Following Living Donor Liver Transplantationen_US
dc.title.alternativeCanlı vericili karaciğer nakli sonrasında erken dönemde gelişen nörolojik komplikasyonların değerlendirilmesien_US
dc.typeArticleen_US

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