Evaluation of Teratogenic and Developmental Toxicity of Everzol Red LFB and Everzol Yellow CGL on Zebrafish (Danio rerio) Embryos

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dc.authorscopusid57203678980
dc.contributor.authorÖzhan Turhan D.
dc.date.accessioned2024-08-04T20:03:46Z
dc.date.available2024-08-04T20:03:46Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSynthetic dyes produced by chemical synthesis are used in textile, food, cosmetic, plastic, and pharmaceutical industries. Of these dyes, azo dyes are a major group of dyes widely used by these industries despite their harm to the environment. A limited number of studies have focused on the impact of dyes on the environment; thus eco-toxicological studies are imperative. The aim of this study was to evaluate the toxic effect of Everzol Red LFB (ERL) and Everzol Yellow CGL (EYC) on zebrafish embryos. Embryos were exposed to 23-600 mg L-1 ERL and EYC for 96 hours and the survival rates, heart rate, hatching rates, and body malformation of these individuals were determined. According to the results of this study, the 96 h LC50 values of the ERL and EYC were determined to be 292 (232-391) and 127 (107-152) mg L-1, respectively. The teratogenic index (TI) values of the ERL and EYC were calculated as 1.37 and 1.49, respectively. ERL and EYC are teratogenic for zebrafish embryos based on the calculated TI value. Both dyes caused significant inhibition of embryonic growth and heart rate in Danio rerio embryos. ERL and EYC caused pericardial edema, yolk sac edema, tail malformation, and spinal curvature in embryos. According to the determined parameters, the negative effect of EYC on zebrafish larvae is greater than of the ERL. These results indicate that both dyes have adverse effects on zebrafish development and may adversely affect the aquatic ecosystem if they enter the aquatic environment. © 2022, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.en_US
dc.description.sponsorshipThe author would like to thank Prof. Dr. Murat ÖZMEN for the laboratory facilities provided, Prof. Dr. Abbas GÜNGÖRDÜ for their support at every stage of the study and article writing, and Nazan BATALOĞLU for the technical support in the laboratory studies.en_US
dc.identifier.doi10.31594/commagene.1081350
dc.identifier.endpage67en_US
dc.identifier.issn2602-456X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85142370495en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage62en_US
dc.identifier.trdizinid1102225en_US
dc.identifier.urihttps://doi.org/10.31594/commagene.1081350
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1102225
dc.identifier.urihttps://hdl.handle.net/11616/92063
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherABADER (Adıyaman Bilimsel Arastırmalar Dernegi)en_US
dc.relation.ispartofCommagene Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdevelopmenten_US
dc.subjectembryotoxicityen_US
dc.subjectpollutionen_US
dc.subjectSynthetic dyeen_US
dc.titleEvaluation of Teratogenic and Developmental Toxicity of Everzol Red LFB and Everzol Yellow CGL on Zebrafish (Danio rerio) Embryosen_US
dc.title.alternativeEverzol Red LFB ve Everzol Yellow CGL'nin Zebra Balığı (Danio rerio) Embriyoları Üzerinde Teratojenik ve Gelişimsel Toksisitesinin Değerlendirilmesien_US
dc.typeArticleen_US

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