Neuroendocrine tumors
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Diffuse neuroendocrine system is an extremely extended system which spread out through whole body. Despite the neuroendocrine tumors (NET) rising from this system can originate from any tissue or organ; gastro-entero-pancreatic region (GEP) especially pancreas is the most common site (70 %). Whitin this region 50 % of the tumors are functioning that means these tumors secreat one or more hormones. The functioning tumors are diagnosed with their specific semptoms which depend on the hormone secreted from. Whereas non-functioning tumors are diagnosed with their mass effects. Enterochromaffin cell carsinoid (EC) is the most frequent (55 %), which followed by insulinoma (15 %), gastrinoma (12 %), and argyrophilic enterochromaffin cell like carcinoid (3.2%), VIPoma (1.4 %), glucagonoma (1.2 %) and somatostatinoma (5.2 %). Approximately 10 % of the functioning GEP-NET's are associated with multiple endocrine neoplasia (MEN) syndromes which suggested to be inherited. Where as 60 % of the sporadic cases are nalignant, the incidence of malignancy in hereditary forms are lesser (45 %). Although the 5 year survival rates are also better in hereditary tumors with a 15 years of life expectancy, the rates changes between 11 to 40 % whitin sporadic cases.
Açıklama
Anahtar Kelimeler
argyrophilic enterochromaffin cell like carcinoid, article, bronchospasm, carcinoid, clinical feature, disease association, enterochromaffin cell, flushing, gastrinoma, glucagonoma, heredity, human, insulinoma, intestine, life expectancy, multiple endocrine neoplasia, neuroendocrine tumor, pancreas, rash, somatostatinoma, stomach, survival rate, survival time, symptom, vipoma, wheezing
Kaynak
SENDROM
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
19
Sayı
6
