Hybrid PLGA nanoparticles as advanced drug delivery and theranostic applications
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nanoparticles are ultradispersed solid supramolecular structures made of organic or inorganic materials, preferably smaller than 500nm. These structures hold great potential for improving the pharmacokinetics and therapeutic index of several drugs including small molecules, genes, peptide- and protein-based therapeutics, and diagnostic agents. Generally, these payloads are covalently or electrostatically grafted on the surface or encapsulated within the nanocarriers. Although each nanocarrier has different advantages and drawbacks depending on its material, and none of them are fully superior to others, poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles are one of the most investigated among them. To overcome the drawbacks of conventional nanocarriers, using more than one nanocarrier material or a complete nanoparticle system to obtain a single nanosystem has become a focus in the last few decades. These systems are called hybrid nanoparticle systems and generally, they have all the benefits of the source materials and component nanoparticle systems. This chapter aims to provide an overview of hybrid nanoparticles and discusses PLGA-based hybrid nanoparticles and their drug delivery and theranostic applications in depth. © 2023 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Core-shell, Drug delivery, Hybrid nanoparticles, PLGA, Tanker and barge
Kaynak
Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery
WoS Q Değeri
Scopus Q Değeri
N/A
