Preparation, characterization, and biocompatibility of chondroitin sulfate-based sol-gel coatings and investigation of their effects on osseointegration improvement

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dc.authoridSEZER, Selda/0000-0002-3136-1250
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridSevimli, Reşit/0000-0002-5394-9100
dc.authoridUnver, Tuba/0000-0002-8655-2716;
dc.authorwosidSEZER, Selda/GQZ-6467-2022
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidSevimli, Reşit/A-5393-2018
dc.authorwosidUnver, Tuba/ABI-6440-2020
dc.authorwosidKARACA ACARİ, Idil/GVU-4371-2022
dc.contributor.authorPasahan, Aziz
dc.contributor.authorSevimli, Resit
dc.contributor.authorKivilcim, Nilufer
dc.contributor.authorAcari, Idil Karaca
dc.contributor.authorErenler, A. Sebnem
dc.contributor.authorSezer, Selda
dc.contributor.authorDurmat, H. Turgut
dc.date.accessioned2024-08-04T20:52:13Z
dc.date.available2024-08-04T20:52:13Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this work, implants with enhanced antibacterial and surface properties besides mechanical, biological, and chemical properties were prepared with the replacement of traditional titanium and titanium alloys in the field of biomedical materials. Titanium substrates were coated with chondroitin sulfate (CS) containing (3-glycidoxypropyl)trimethoxysilane (GLYMO) and tetraethoxysilane (TEOS) based thin film using sol-gel technology. Chondroitin sulfate is a preferred material due to its characteristics antioxidative and osseointegresion properties besides its collagen-forming properties. Coated implants were morphologically elucidated with atomic force microscopy (AFM), and scanning electron microscopy (SEM). The structure of the chondroitin sulfate-containing films was investigated with Fourier Transform Infrared Spectroscopy (FTIR) and Energy Dispersive X-Ray Analysis (EDX) techniques. The obtained CS-based sol-gel surface coatings are thermally stable up to similar to 200 degrees C according to TGA and DTA analysis results. The biological and antibacterial properties of the coatings were also determined. The biocompatibility and osseointegration properties of the coatings developed within the scope of the study were, determined by in vivo studies on rats. According to biocompatibility results of CS/Sol-Gel coated surfaces, Cell viability (%) rates of CS-based coatings showed between 89 and 66%. According to the experimental data, it has been claimed that implants improved with antibacterial, stable, homogeneous, and biocompatible coatings can be used as a new alternative product for dental and orthopedic applications.en_US
dc.description.sponsorshipInonu University Research Fund [FOA2018-1325]en_US
dc.description.sponsorshipWe gratefully to Inonu University Research Fund (Project No: FOA2018-1325).en_US
dc.identifier.doi10.1080/00914037.2022.2105332
dc.identifier.endpage1528en_US
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.issue18en_US
dc.identifier.scopus2-s2.0-85135161265en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1510en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2022.2105332
dc.identifier.urihttps://hdl.handle.net/11616/100812
dc.identifier.volume72en_US
dc.identifier.wosWOS:000832930300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial propertyen_US
dc.subjectchondroitin sulfateen_US
dc.subjectmetallic implanten_US
dc.subjectsol-gel chemistryen_US
dc.titlePreparation, characterization, and biocompatibility of chondroitin sulfate-based sol-gel coatings and investigation of their effects on osseointegration improvementen_US
dc.typeArticleen_US

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