Evaluation of protective effects of verapamil against lens epithelial tissue injury induced by irradiation in rats
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Pharmacists Association
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, we investigated the possible protectant effects of verapamil against lens epithelial tissue injury induced by irradiation in rats. Forty female Wistar Albino rats were divided into four groups (n=10). Group 1 received 10 mg/kg verapamil and underwent 20 Gy irradiation. Group 2 received no verapamil and underwent 20 Gy irradiation. Group 3 received 10 mg/kg verapamil and underwent sham irradiation. Group 4 received no verapamil and underwent sham irradiation. The lens tissues were dissected and measured malondialdehyde levels in all groups. The mean malondialdehyde levels (nmol/mg prt) were determined as 5,59 for Group 1, 7,04 for Group 2, 3,95 for Group 3 and 3,25 for Group 4. In conclusion, we can suggest that verapamil as a protectant agent against radiation induced lens epithelial tissue injury.
Açıklama
Anahtar Kelimeler
Lens injury, Lipid peroxidation, Radiation, Verapamil
Kaynak
Turkish Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
7
Sayı
3
