Occupational prolonged organic solvent exposure in shoemakers brain MR spectroscopy findings
Yükleniyor...
Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Magnetic Resonance Imaging
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Our purpose was to investigate, by magnetic resonance (MR) spectroscopy, the metabolite changes in the brains of subjects in the
shoemaking industry who had been chronically exposed to organic solvents. A total of 49 male subjects and 30 age-matched healthy
volunteers underwent detailed neurological and psychiatric examinations. All subjects had long-echo [repetition time (TR) 2000 ms, echo
time (TE) 136 ms] single-voxel MR spectroscopy. Voxels (15 15 15 mm3
) were placed in the parietal white matter, thalamus, and basal
ganglia. N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were calculated. There was no significant difference between
the study subjects and the control group in NAA/Cr ratios obtained from thalamus, basal ganglia, and parietal white matter. Cho/Cr ratios
in thalamus, basal ganglia, and parietal white matter were found to be significantly increased compared to controls. There was a positive correlation
between basal ganglia Cho/Cr ratio and duration of exposure (r 0.63). MR spectroscopy should be performed to reveal metabolite changes
and determine the degree of brain involvement in solvent-related industry workers.
Açıklama
Anahtar Kelimeler
Occupational exposure, Solvents, Magnetic resonance spectroscopy
Kaynak
Magnetic Resonance Imaging
WoS Q Değeri
Scopus Q Değeri
Cilt
22
Sayı
5
Künye
Alkan, A. Kutlu, R. Tarık, H. Sığırcı, A. Emul, M. Pala, N. Altınok, T. Aslan, M. Saraç, K. Özcan, A. (2004). Occupational prolonged organic solvent exposure in shoemakers brain MR spectroscopy findings. Magnetic Resonance Imaging, 22(5), 707–713.
